| 摘要: |
| 目的：了解南宁地区儿童呼吸道感染苛养菌分布及耐药性特点。方法：对2013年8月至2014年7月在广西壮族自治区妇幼保健院住院的呼吸道感染患儿5 235例痰标本苛养菌培养及药敏结果进行回顾分析。结果：5 235例标本共分离出肺炎链球菌226例、流感嗜血杆菌126例、副流感嗜血杆菌34例和卡他布兰汉菌21例。肺炎链球菌对万古霉素均敏感，对喹诺酮类、青霉素、氯霉素、头孢菌素类、酶抑制剂类较敏感，对阿奇霉素、复方磺胺甲恶唑、红霉素、克林霉素、四环素耐药率超过90%。流感嗜血杆菌、副流感嗜血杆菌、卡他布兰汉菌对头孢噻肟、阿莫西林/克拉维酸、亚胺培南敏感，对氨曲南耐药率均超过60%。流感嗜血杆菌、副流感嗜血杆菌、卡他布兰汉菌产β-内酰胺酶检出率分别为40.48%、38.24%和61.90%（P<0.05）。结论：儿童呼吸道感染苛养菌以肺炎链球菌为主，有其独特耐药谱，临床应明确病原学诊断，根据药敏结果选用敏感抗菌药物。 |
| 关键词: 儿童 呼吸道感染 苛养菌 耐药性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.01.018 |
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| 基金项目: |
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| Distribution and Drug Resistance of Fastidious Bacteria from Children with Respiratory Tract Infection in Nanning Area |
| Huang Liying, Li Dongming, Hu Xuehua, Wu Li, Huang Weizhen |
| (Maternal and Children Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Nanning 530012, China) |
| Abstract: |
| bjective: To investigate the distribution and drug resistance of fastidious bacteria from children with respiratory tract infection in Nanning area. Methods: Culture and antibiotic sensitive test of fastidious bacteria were performed retrospectively in 5,235 sputum of children with respiratory tract infection. Results: Among the 5,235 samples, Streptococcus pneumonia (226 cases), Haemophilus influenza (126 cases), Haemophilus parainfluenzae (34 cases) and Moraxelle catarrhalis (21 cases) were identified. No Streptococcus pneumoniae showed resistant to vancomycin, and sensitivity to quinolone, penicillin, chloramphenicol, cephalosporins and enzyme inhibitors, but resistant to azithromycin, compound sulfanilamide, erythromycin, clindamycin, and tetracycline (above 90%). Haemophilus influenza, Haemophilus parainfluenzae and Moraxelle catarrhalis were sensitivity to cefotaxime, amoxicillin/clavulanic acid and imipenem, and resistant to aztreonam (above 60%). The rate of ESBLs production of Haemophilus influenza, Haemophilus parainfluenzae and Moraxelle catarrhalis was 40.48%, 38.24% and 61.90% respectively (P>0.05). Conclusion: Streptococcus pneumonia is the main fastidious bacteria in children with respiratory tract infection, and the drug resistant was unique. Etiology diagnosis should be performed. Antibiotic was used according to the results of antibiotic sensitive test. |
| Key words: Children Respiratory tract infections Fastidous bacteria Drug resistance |
