| 摘要: |
| 目的：了解新生儿科重症监护病房（ICU）用药情况，为促进我院新生儿科ICU合理使用药物提供依据。方法：将新生儿科用药按照药理作用机制进行分类统计，根据用药数量进行排序并计算百分比，统计分析2010年至2013年用药频度数量排名前10位的药品。查阅各药品说明书，核对各药品的实际使用情况，统计新生儿科ICU超说明书使用情况。结果：从2010年到2013年，新生儿科ICU用药数量呈上升趋势，维生素及水电解质平衡营养药物、作用于消化系统药物、作用于血液造血系统药物居前3位，最大的DDDs排名前3位的三种药物分别为维生素AD滴剂、枯草杆菌二联活菌颗粒和复方碳酸钙泡腾颗粒。2012-2013年，抗感染药物、作用于自主神经系统药物、用于消化系统药物增幅分别为55.53%、43.62%和28.68%。说明书中未提及到新生儿用药的48种，占31.6%，主要包括维生素、水电解质平衡营养类药物、血液造血系统和消化系统药物。结论：我院新生儿科ICU用药特点比较明确，超说明书用药所占比例较大，应加强不合理用药的干预，进一步提高我院新生儿用药的安全性、有效性和经济性。 |
| 关键词: 新生儿 重症监护病房 合理用药 超说明书用药 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.12.016 |
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| 基金项目: |
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| Analysis of Drug Use of Neonatal Intensive Care Unit in our Hospital During 2010-2013 |
| Tang Hongbo, Zhuang Taifeng, Wang fang, Zhu Jianguo, Chong Lingli, Sun Xuemei, Feng Xin |
| (Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China) |
| Abstract: |
| Objective: To investigate the information of drug use in neonatal intensive care unit (ICU) , in order to provide the basis for promoting the rational use of drugs. Methods: Classify and statistic frequency of drugs according to the pharmacological mechanism, calculate the percentage of each kind of drugs, analyses the 10 best-selling prescription drugs from 2010 to 2013 by medication fequency (DDDs) analysis method. Check the instructions and the actual usage of each drug, statistic the off-label use of drugs in ICU including category and the main drug varieties. Results: From 2010 to 2013, the amount of drugs in new pediatric ICU is on the rise. The vitamin, water and electrolyte balance nutrition, the digestive system drugs and the drugs on blood hematopoietic system are the most important three categories. Vitamin AD drops, combined bacillus subtilis and enterococcus faecium granules with multivitamines, compound calcium carbonate effervescent Granules are the most popular three drugs. From 2012 to 2013, anti-infection drugs, drugs on the autonomic nervous system and in the digestive system drugs increased 55.53%, 43.62% and 28.68%, respectively. There are 48 drugs with off-label use, accounting for 31.6%. These drugs mainly include vitamins, water and electrolyte balance nutrition drugs, blood hematopoietic system and digestive system drugs. Conclusion: The characteristics of drug use in new pediatric ICU are distinct and the percentage of off-label use is high. Don’t rational drug use intervention should be strengthened, and further improve our newborn drug safety, effectiveness and economy. |
| Key words: neonatal intensive care unit rational drug use off-label use |
