| 摘要: |
| 目的：探讨肺炎支原体肺炎患儿中P2X7受体表达水平及与TNF-α、IL-1β水平的相关性。方法：选取300例肺炎支原体肺炎患儿作为研究组并选取健康儿童50例作为对照组，检测两组间P2X7受体、TNF-α和IL-1β表达水平的差异及相关性。结果：研究组P2X7受体表达水平为（151.4±14.3）ng/mL，显著高于对照组的（64.7±10.8）ng/mL（P<0.01）；研究组TNF-α表达水平为（1.72±0.14）ng/mL，显著高于对照组的（0.74±0.16）ng/mL（P<0.01）；研究组IL-1β表达水平为（0.89±0.14）ng/mL，显著高于对照组的（0.23±0.15）ng/mL（P<0.01）。肺炎支原体肺炎患儿中P2X7受体表达与TNF-α、IL-1β表达水平呈正相关（R2分别为0.533、0.666，P<0.05）。结论：肺炎支原体肺炎患儿中存在P2X7受体及TNF-α、IL-1β过度表达，且P2X7受体与TNF-α、IL-1β表达呈正相关。 |
| 关键词: 肺炎支原体 P2X7受体 TNF-α IL-1β |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.06.003 |
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| 基金项目:东莞市科技计划项目，项目编号201510515000237 |
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| Early Diagnosis of Mycoplasma Pneumonia and P2X7 Receptor Expression |
| Zhou Yueqin, Wang Qin, Fang Xin |
| ((The Houjie Hospital of Dongguan, Guangdong province, Guangdong Dongguan 523945, China) |
| Abstract: |
| Objective: To study the expression level of P2X7 receptor, TNF-α, IL-1β and their relationship in mycoplasma pneumonia patients. Methods: A total of 300 children with mycoplasma pneumonia were set as study group and 50 children without mycoplasma pneumonia were set as control group. The expression level of P2X7 receptor, TNF-α, IL-1β and their relationship were measured. Results: The expression level of P2X7 receptor in study group was (151.4±14.3) ng/mL which was significantly higher than (64.7±10.8) ng/ml in control group (P<0.01). The expression level of TNF-α in study group was (1.72±0.14) ng/mL which was significantly higher than (0.74±0.16) ng/mL in control group (P<0.01). The expression level of IL-1β in study group was (0.89±0.14) ng/mL which was significantly higher than (0.23±0.15) ng/ml in control group (P<0.01). The P2X7 receptor expression level was positively related with TNF-α and IL-1β (R2=0.533, P<0.05; R2=0.666, P<0.05). Conclusion: The expression level of P2X7 receptor, TNF-α, IL-1β in mycoplasma pneumonia children were significantly increased and P2X7 receptor is positively related with TNF-α and IL-1β. |
| Key words: Mycoplasma pneumonia P2X7 receptor TNF-α IL-1β |
