| 摘要: |
| 目的：探讨孟鲁司特与维生素D联合治疗婴幼儿喘息性疾病临床效果。方法：选取婴幼儿喘息性疾病患儿140例，采用随机数字表法分为对照组和试验组各70例，两组患儿均给予常规对症支持治疗，对照组患儿同时给予孟鲁司特治疗，试验组患儿同时给予孟鲁司特联合维生素D治疗，比较两组患儿临床疗效、症状体征消失时间、住院时间，随访复发率，检测治疗前后血清碱性磷酸酶、25-羟维生素D3[25-(OH)D3]及IgA水平。结果：试验组患儿总有效率92.86%，显著优于对照组的72.86%（P<0.05）；试验组患儿症状体征消失时间和住院时间短于对照组，差异有统计学意义（P<0.05）；试验组患儿随访3个月和6个月复发率低于对照组，差异有统计学意义（P<0.05）；试验组患儿治疗后血清碱性磷酸酶、25-(OH)D3及IgA水平均显著高于对照组和治疗前，差异均有统计学意义（P<0.05）。结论：孟鲁司特与维生素D联合治疗婴幼儿喘息性疾病可显著缓解症状体征，促进病情康复，并有助于降低复发风险和改善实验室指标。 |
| 关键词: 孟鲁司特 维生素D 婴幼儿 喘息性疾病 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.02.006 |
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| 基金项目: |
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| Clinical Study of Montelukast Combined with Vitamin D in the Treatment of Infants with Asthmatic Diseases |
| Zhu Xueping |
| (Ninghai County Maternal and Child Health Hospital, Zhejiang Ninghai 315600, China) |
| Abstract: |
| Objective: To investigate clinical effects of montelukast combined with vitamin D in the treatment of infants with asthmatic diseases. Methods: 140 infants with asthmatic diseases were chosen and randomly divided into both group including control group (70 cases) with montelukast used alone and treatment group (70 cases) with montelukast combined with vitamin D on the basis of routine symptomatic intervention; and the clinical efficacy, disappeared time of symptoms and signs, hospitalization time, recurrence rate, the levels of alkaline phosphatase, 25-(OH)D3 and IgA before and after treatment of both groups were compared. Results: The clinical efficacy of treatment group (92.86%) was significantly better than control group (72.86%, P<0.05). The disappeared time of symptoms and signs and hospitalization time of treatment group was significantly shorter than control group (P<0.05). The recurrence rate of treatment group was significantly lower than control group (P<0.05). The levels of alkaline phosphatase, 25-(OH)D3 and IgA after treatment of treatment group was significantly better than control group and before treatment (P<0.05). Conclusion: Montelukast combined with vitamin D in the treatment of infants with asthmatic diseases can efficiently relieve the symptoms and signs, promote the recovery process of disease, and be helpful to reduce recurrence risk and improve laboratory index. |
| Key words: Montelukast Vitamin D Infants Asthmatic diseases |
