| 摘要: |
| 目的：探讨影响不同分度早产儿支气管肺发育不良（BPD）的临床高危因素，为临床防治提供参考。方法：选取重庆医科大学附属儿童医院2013-2014年收治的BPD早产儿81例，按照临床分度标准分为轻度组24例和中重度组57例，对其围产期情况、母孕期情况、合并症、临床治疗及预后情况进行回顾性分析。结果：中重度组呼吸窘迫综合征（RDS）、呼吸衰竭、动脉导管未闭（PDA）、先天性心脏病、肺出血、消化道出血的患儿比例高于轻度组，机械通气时间长于轻度组，日增长体质量低于轻度组（P均<0.05）。两组在性别、胎龄、胎数、出生体质量、母亲年龄、产前激素及出生后肺表面活性剂的应用等方面比较差异均无统计学意义（P均>0.05）。结论：对于减少早产儿BPD，积极防治RDS、肺出血、消化道出血、PDA等并发症是的关键，其中尽可能缩短机械通气时间是重要措施之一。 |
| 关键词: 支气管肺发育不良 危险因素 早产儿 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.04.006 |
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| 基金项目: |
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| Risk Factors of Bronchopulmonary Dysplasia in Preterm Infants with Different Severities |
| Yue Weihong |
| (Children’s Hospital of Chongqing Medical University, Chongqing 400014, China) |
| Abstract: |
| Objective: To improve the prevention and treatment of bronchopulmonary dysplasia (BPD) in preterm infants, the clinical risk factors of premature neonates with different severities of BPD were investigated. Methods: A total of 81 cases among preterm infants who were admitted to NICU in the Children Hospital of Chongqing Medical University from Jan. 2013 to Dec. 2014 were analyzed retrospectively. The history of birth and mother pregnancy, clinical treatment, prognosis and complication of mild, moderate and severe BPD according to clinical diagnostic criteria were analyzed retrospectively. Results: In the total 81 premature neonates, 24 cases were diagnosed as mild BPD. 57 cases were moderate and severe BPD. With the increasing severity of BPD, RDS, PDA, respriatory failure, pulmonary hemorrhage, gastrointestinal hemorrhage and mechanical ventilation time were increasing (all P<0.05). Conclusion: Preventing and reducing complications as RDS, PDA, pulmonary hemorrhage and gastrointestinal hemorrhage, shorten the duration of mechanical ventilation are the key factors to reduce severities of BPD in preterm infants. |
| Key words: bronchopulmonary dysplasia risk factor preterm infant |
