| 摘要: |
| 目的：了解儿童肺炎链球菌（S. pneumoniae，SPN）对临床常用抗菌药物的耐药情况，为抗菌药物合理使用提供参考。方法：对2013年10月至2015年5月我院儿科病房分离的74株肺炎链球菌进行抗菌药物敏感性试验，按照2012年CLSI标准进行判读。结果：SPN对常用抗菌药物如红霉素、青霉素、阿莫西林、头孢曲松、头孢噻肟的耐药率分别为95.5%、62.1%、35.3%、24.2%和21.2%；对青霉素耐药的SPN对阿莫西林、头孢曲松、头孢噻肟的耐药率均明显增加，约为青霉素敏感SPN的5～8倍；并且对美罗培南的耐药率为26.8%；但尚未检测出厄他培南、万古霉素、利奈唑胺及左氧氟沙星等的耐药菌株。结论：儿童SPN对常用抗菌药物呈现不同程度的耐药，临床应根据药敏结果合理使用抗菌药物，减少耐药菌株的产生。 |
| 关键词: 儿科 肺炎链球菌 耐药性 抗菌药物 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.04.014 |
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| 基金项目: |
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| Drug Resistance of S. Pneumoniae Isolated From the Department of Pediatrics |
| Long Yandan, Tang Xiaofei, Zhang Yan, Chen Xiaoying |
| (Fengdu People’s Hospital of Chongqing, Chongqing 408299, China) |
| Abstract: |
| Objective: To investigate the drug resistance of S. pneumoniae (SNP) isolated from the department of pediatrics, so as to provide basis for rational use of antibiotics. Methods: The drug sensitivity test was performed for the 74 strains of SNP isolated from the department of pediatrics, between October 2013 to May 2015. The result was determined according to CLSI 2012, and was analyzed retrospectively. Results: The drug resistance rate of SNP to erythromycin, penicillin, amoxicillin, ceftriaxone and cefotaxime was 95.5%, 62.1%, 35.3%, 24.2% and 21.2%, respectively. The drug resistance of penicillin resistant S. pneumonia (PRSP) to amoxicillin, ceftriaxone and cefotaxime was increased significantly, which was about 5~8 times of penicillin sensitive S. pneumonia (PSSP). The drug resistance of PRSP to meropenem was 26.8%, but the drug resistant SNP to vancomycin, linezolid, telithromycin, levofloxacin and moxifloxacin hadn’t been detected. Conclusion: The SNP isolated from the department of pediatrics showed different drug resistance to common antibiotics. The rational use of antimicrobial agents should be according to the result of drug sensitivity test, so as to reduce the drug resistance. |
| Key words: Pediatrics S. pneumoniae Drug resistance Antibacterial agents |
