| 摘要: |
| 目的：探讨血清肿瘤坏死因子-α（TNF-α）和N末端脑利钠肽（NT-proBNP）在川崎病（KD）发病中的临床意义。方法：选择确诊为KD的48例患儿为KD组，并以年龄相仿的门诊体检健康儿童20例为对照组。采用双抗体夹心酶联免疫吸附法和全自动化学发光免疫分析仪对两组儿童血清TNF-α、NT-proBNP和肌钙蛋白I（cTnI）进行检测，并通过超声心动图检测冠状动脉情况，将KD组分为冠状动脉损害（CAL）组和无冠状动脉损害（NCAL）组。结果：急性期KD患儿的血清TNF-α、NT-proBNP和cTnI水平分别为（2.11±0.76）μg/L、（0.88±0.19）μg/L、（0.28±0.16）μg/L，均显著高于恢复期KD组[（0.90±0.32）μg/L、（0.16±0.07）μg/L、（0.14±0.04）μg/L]和对照组[（0.75±0.38）μg/L、（0.12±0.05）μg/L、（0.13±0.05）μg/L]。CAL组血清TNF-α、NT-proBNP和cTnI水平分别为（2.83±0.45）μg/L、（0.97±0.19）μg/L、（0.35±0.19）μg/L，显著高于NCAL组的（1.67±0.54）μg/L、（0.83±0.17）μg/L、（0.24±0.13）μg/L。KD患儿急性期血清TNF-α、NT-proBNP水平与cTnI水平均呈显著正相关（r分别为0.641、0.731，P<0.01）。结论：血清TNF-α和NT-proBNP水平与KD患儿的心血管损害关系密切，对预测KD患儿心肌和冠状动脉损伤有重要的临床价值。 |
| 关键词: 川崎病 肿瘤坏死因子-α N末端脑利钠肽 心血管损害 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.06.010 |
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| 基金项目: |
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| Levels of Serum Tumor Necrosis Factor-A, N-Terminal Pro-Brain Natriuretic Peptide and Its Clinical Significance in Children with Kawasaki Disease |
| HONG Ze1, SUN Xing-Zhen1, CHEN Xue-Ying2 |
| (1. Huai’an First People’s Hospital, Nanjing Medical University, Jiangsu Huai’an 223300, China; 2. Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210008, China) |
| Abstract: |
| Objective: To explore Levels of serum tumor necrosis factor-α (TNF-α), N-terminal pro-brain natriuretic peptide (NT-proBNP) and its clinical significance in children with Kawasaki disease. Methods: Forty-eight children with KD and twenty healthy children were enrolled. The levels of serum TNF-α, NT-proBNP and cardiac tropnin I (cTnI) were measured by enzyme-linked immunosorbent assay, immune and automated chemiluminescence immunoassay, respectively. The KD group was classifed into two subgroups, with or without coronary artery lesions, based on the findings of the echocardiography. The coronary artery was checked by Doppler echocardiography. Results: In acute phase, the levels of serum TNF-α (2.11±0.76) μg/L, NT-proBNP (0.88±0.19) μg/L and cTnI (0.28±0.16) μg/L in children with KD were significantly higher than those in recovery [(0.90±0.32) μg/L, (0.16±0.07) μg/L, (0.14±0.04) μg/L] and control group [(0.75±0.38) μg/L, (0.12±0.05) μg/L, (0.13±0.05) μg/L]. The levels of serums TNF-α (2.83±0.45) μg/L, NT-proBNP (0.97±0.19) μg/L and cTnI (0.35±0.19) μg/L in children with CAL were significantly increased, compared with KD children without CAL [(1.67±0.54) μg/L, (0.83±0.17) μg/L, (0.24±0.13) μg/L]. The levels of serum TNF-α, NT-proBNP were positively correlated with the levels of senlm cTnI (r=0.641, r=0.731, P<0.01). Conclusion: The levels of serum TNF-α and NT-proBNP are not only closely associated with cardiovascular damage but also can be taken as the indicators for diagnosis of myocardiac damages and CALs in children with KD. |
| Key words: Kawasaki disease tumor necrosis factor-α N-terminal pro-brain natriuretic peptide cardiovascular damage |
