| 摘要: |
| 目的：探讨盐酸右美托咪定（DEX）应用于小儿扁桃体切除术前镇静的效果与安全性。方法：选取2012年2月至2015年2月在我院行扁桃体切除术的2~10岁儿童85例，根据术前镇静用药分为DEX组45例和氯胺酮组40例，比较分析两组患儿的术前镇静效果、术中临床指标、苏醒时间、术后不良反应等。结果：DEX组术前镇静效果优于氯胺酮组，插管后及拔管后10 min的血压、心率均高于氯胺酮组，拔管恢复、呼吸恢复、意识恢复时间均短于氯胺酮组（P均<0.05）。两组术后哭闹发生率比较差异无统计学意义（P>0.05）；DEX组术后躁动、恶心、呕吐的发生率均低于氯胺酮组（P均<0.05）。结论：DEX可安全应用于小儿扁桃体切除术前镇静，可降低术后躁动、恶心、呕吐等不良反应的发生率。 |
| 关键词: α2受体激动剂 盐酸右美托咪定 扁桃体切除 镇静 安全性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.11.007 |
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| 基金项目: |
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| The Clinical Application of α2-Agonist of Preoperative Sedative Effect and Safety in the Pediatric Tonsillectomy Gland Surgery |
| Cao Shumei1, Li Shasha, Lu Rongjun |
| (The First Hospital of Xi’an, Shanxi Xi’an 710002, China) |
| Abstract: |
| Objective: To explore the clinical application of alpha 2 agonists of preoperative sedative effect and safetyin in pediatric tonsillectomy gland surgery. Methods: Randomly selected 85 cases of 2-10 years old children of the hospital from February 2012 to 2015 February. Including 38 males and females 47 cases. Wherein dexmedetomidine hydrochloride administration group 45 cases, as the observation group, ketamine treatment group 40 cases, as the control group. Compared with the two groups of children with preoperative sedation, surgery clinical indicators, stopping to sober time, postoperative adverse reactions. Results: The effect of the observation group was better than that of the control group (P<0.05). There was no significant difference in the clinical indexes of two groups (P>0.05) in the 10 minutes before entering the operation room. The blood pressure and heart rate of the observation group were higher than those of the control group (P<0.05) after 10 min of intubation and extubation. Withdrawal to awake time in the control group were higher than in the observation group (P<0.05). There was no difference in the incidence of postoperative crying between the two groups (P>0.05). In observation group, the incidence of postoperative agitation rate was 13.33%, the incidence of nausea was 11.11%, and the incidence of vomiting was 20.00%. These incidence of these adverse reactions in observation group were lower than that in control group (P<0.05). Conclusion: Dexmedetomidine hydrochloride can be safely used in children before surgery sedation, and can reduce the incidence of postoperative adverse reactions, as restlessness, nausea, vomiting. |
| Key words: α2-agonist dexmedetomidine hydrochloride tonsillectomy gland surgery sedative safety |
