| 摘要: |
| 目的:分析儿童类固醇性糖尿病的临床特点,提高对该病的认识。方法:回顾性分析山西省儿童医院收治的2例类固醇糖尿病患儿临床表现、体征、实验室检查结果。结果:2例儿童类固醇性糖尿病均无多饮、多尿及体质量减轻等糖尿病典型临床表现,均以餐后血糖明显升高为主要临床表现。1例患儿于糖皮质激素治疗2个月后发生,激素总量1 700 mg,胰岛素治疗7周后血糖恢复正常;另1例患儿于激素治疗20 d后发生,激素总量1 000 mg,激素减量12周后,血糖恢复正常。结论:大剂量长疗程使用糖皮质激素易引起类固醇糖尿病,激素减量可能使血糖恢复正常,胰岛素为治疗类固醇糖尿病的首选药物。 |
| 关键词: 类固醇糖尿病 糖皮质激素 胰岛素 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.09.010 |
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| 基金项目: |
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| steroid diabetes; glucocorticoid; insulin |
| Zhang Gaixiu1 , Hu Dongyang2 , Zhang Mingchen2 , Wang Lei1 , Guo Tingting2 |
| (1. Children's Hospital of Shanxi Province, Shanxi Taiyuan 030013, China; 2. Shanxi Medical University, Shanxi Taiyuan 030001, China) |
| Abstract: |
| Objective: To analyze the clinical characteristics of steroid diabetes in children and to improve our understanding of this disease. Methods: The clinical manifestations and laboratory test results of two cases of child steroid diabetes admitted by Children’s Hospital of Shanxi Province were retrospectively analyzed. Results: Neither case showed polydipsia, polyuria, weight loss or other typical manifestations of diabetes except significant postprandial hyperglycemia. One case occurred 2 months after administration of 1,700 mg glucocorticoid during horme therapy, and recovered after 7 weeks of insulin therapy, the other case occurred 20 days after administration of 1,000 mg glucocorticoid, and recovered 12 weeks after reducing glucocorticoid dose. Conclusion: Long-term, high-dose use of glucocorticoid may cause steroid diabetes, which would recover after reducing glucocorticoid dose, and insulin is the drug of choice. |
| Key words: steroid diabetes glucocorticoid insulin |
