| 摘要: |
| 目的:探讨14种食物过敏原特异性IgG抗体检测的食物干预治疗与儿童炎症性肠病(IBD)的关系。方法:采用酶联免疫吸附试验(ELISA)法检测IBD患儿血清中食物过敏源特异性IgG抗体浓度,根据IgG浓度分为0级、+1级、+2级、+3级共4级。对0级判断为阴性,而+1级、+2级、+3级则判断为阳性。选取我院收治的27例IBD患儿纳入观察组,根据是否进行食物干预治疗分为观察A组和观察B组,观察A组采用常规治疗方法,观察B组在常规治疗方法上加健康饮食指导,即根据食物过敏原特异性IgG抗体检测结果0级、+1级、+2级、+3级分别采取“安全进食冶、“轮替冶、“忌食冶的健康饮食指导,观察A、B两组患儿临床症状缓解情况。选取健康体检儿童20例为对照组。结果:27例IBD患儿中24例有1~9种的食物过敏特异性IgG升高,阳性率为88.9%,高于对照组的25.0%(P<0.01)。27例IBD患儿食物过敏特异性IgG阳性率不同,其中以牛奶、鸡蛋最高(分别为77.8%和74.1%),而鸡肉、猪肉最低(3.7%)。单种食物IgG阳性率比较发现,观察组患儿蟹、鸡蛋、牛奶、大米、虾、大豆、西红柿的IgG阳性率高于对照组(P<0.05);其余食物阳性率在不同组间比较差异无统计学意义(P>0.05)。通过健康饮食指导处理的观察B组患儿在第2、4、8周临床症状缓解率分别为60.0%、66.7%、86.7%,而常规治疗的观察A组则为16.7%、25.0%、41.7%,观察B组的临床缓解率高于A组(P<0.05)。结论:在儿童IBD中,食物过敏原特异性IgG抗体升高是常见的,食物过敏影响IBD的发生发展,进行食物干预有助于临床症状的改善。 |
| 关键词: 食物干预 过敏原特异性IgG抗体 儿童 溃疡性结肠炎 克罗恩病 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.10.003 |
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| 基金项目: |
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| Food Intervention Therapy in Inflammatory Bowel Disease in Children |
| Tang Shuo, Ouyang Wenxian, You Jieyu, Duan Baipin, Xu Bin |
| (Children's Hospital of Hunan Province, Hunan Changsha 410007, China) |
| Abstract: |
| Objective: To explore the link between the 14 kinds of food allergen-specific IgG antibodies and inflammatory bowel disease(IBD) in children. Methods: Serum levels of specific IgG antibodies to 14 kinds of food were detected by using ELISA. The results were classified into four grades: grade 0 (negative), grade +1 (positive), grade +2 (positive), grade +3 (positive). Using the conventional treatment in group A, while the children of group B received a diet treatment based on the results of food allergen-specific IgG antibody detection except conventional treatment. Children with grade 0, grade +1, grade +2, grade +3, were taken to continue their current diet, safe to eat, rotation, avoid eating, respectively. Then we observed the changes of clinical symptoms in two groups. Results: Of the 27 children with IBD, 24 (88.9%) had increased food allergy-specific IgG levels for 1 to 9 kinds food tested compared to 5 (25.0%) of the control group (P<0.01). The majority of children with IBD showed increased food allergy-specific IgG levels for milk (77.8%) and eggs (74.1%). A low proportion of patients (3.7%) was allergic to chicken and pork. The symptoms were improved in 60.0%, 66.7%, 86.7% of children in group B compared to 16.7%, 25.0%, 41.7% of children in group A, respectively, after 2, 4, 8 weeks’ treatment (P<0.05). Conclusion: The increase of food allergen-specific IgG antibodies level is common in children with inflammatory bowel disease. Food allergies affect the occurrence and development of inflammatory bowel disease, diet treatment can improve clinical symptom. |
| Key words: food intervention allergen-specific IgG antibody child ulcerative colitis Crohn's disease |
