| 摘要: |
| 目的:观察成分输血对早产儿血液流变学参数的影响,探讨相关临床意义。方法:收集2013 年1月至2015年9月我院儿科需要输血治疗的早产儿108例,采用随机数表法分为红细胞悬液组和洗涤红细胞组各54例,两组患儿给予相应的成分输血。观察两组患儿治疗前后亚硝基硫醇(RSNO)、超氧化物歧化酶(SOD)、丙二醛(MDA)、全血高切黏度、全血低切黏度、血浆黏度的变化,比较两组患儿的机械通气时间、住院时间、院内感染率和病死率。结果:洗涤红细胞组机械通气时间、住院时间、院内感染率和病死率分别为(5.67±1.14)d、(31.26±5.14)d、25.93%和9.26%,均短于(或低于)红细胞悬液组的(8.22±1.58)d、(40.17±7.22)d、37.04%和16.67%(P均<0.05)。治疗前,两组患儿全血高切黏度、全血低切黏度、血浆黏度比较差异均无统计学意义(P均>0.05);治疗后,两组患儿上述血液流变学参数均减小,且洗涤红细胞组小于红细胞悬液组(P均<0.05)。治疗前,两组患儿RSNO、SOD、MDA比较差异均无统计学意义(P均>0.05);治疗后,红细胞悬液组RSNO和SOD降低,MDA升高(P均<0.05),而洗涤红细胞组变化无统计学意义(P均>0.05)。结论:红细胞悬液可加重患儿体内的应激反应,洗涤红细胞较红细胞悬液更有利于血液流变学参数的改善,对于符合输血指征的早产儿,推荐使用洗涤红细胞纠正贫血。 |
| 关键词: 早产儿 红细胞悬液 洗涤红细胞 血液流变学 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.09.002 |
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| 基金项目: |
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| The Effect and Clinical Application of Component Blood Transfusion on Blood Rheology Parameters in Premature Infants |
| Huang Rong, Zhang Mingchun, Liu Jian |
| (Jianshi People's Hospital of Hubei Province, Hubei Jianshi 445300, China) |
| Abstract: |
| Objective: To observe the effect of component blood transfusion on blood rheology parameters in premature infants and explore its clinical efficacy. Methods: A total of 108 premature infants who need a blood transfusion treatment were enrolled from our hospital. Infants were randomly divided into suspension red blood cell group (n=54) and washed red blood cell group (n=54). The RSNO, SOD, MDA, high blood viscosity, low blood viscosity, and plasma viscosity were compared. The nosocomial infection rate, mechanical ventilation time, hospitalization time and mortality were compared. Results: The nosocomial infection rate, mechanical ventilation time, hospitalization time and mortality in washed red blood cell group were 25.93%, (5.67±1.14) d, (31.26±5.14) d, and 9.26%, respectively, which were lower than those of 37.04%, (8.22±1.58) d, (40.17±7.22) d, and 16. 67% in suspension red blood cell group (P<0.05). After treatment, high blood viscosity, low blood viscosity, and plasma viscosity were lower in washed red blood cell group than those in suspension red blood cell group (P<0.05). RSNO and SOD were lower, MAD was high in suspension red blood cell group after treatment (P<0.05). However, RSNO, SOD and MAD had no differences in washed red blood cell group (P<0.05). Conclusion: Suspension red blood cell can aggravate the stress reaction in premature infants. Washed red blood cell was beneficial to the improvement of blood rheology parameters, which was recommended to correct anemia in premature infants. |
| Key words: premature infants suspension red blood cell washed red blood cell blood rheology |
