| 摘要: |
| 目的:探讨T淋巴细胞、血清炎症因子与胃肠炎伴良性惊厥的相关性。方法:选取我院2013年1月至2015年8月收治的36例肠胃炎伴良性惊厥患儿为研究组,选取同期健康体检儿童25例为对照组,应用McAb-APAAP法和化学发光法检测T淋巴细胞亚群(CD3+ 、CD4+ 、CD4+ /CD8+ )及血清炎症因子(IL-6、TNF-α与IFN-γ)水平,比较两组各指标水平差异,并分析胃肠炎伴良性惊厥患儿惊厥发生次数和持续时间与上述指标的相关性。结果:研究组CD3+细胞计数、CD4+细胞计数、CD4+ /CD8+ 值均低于对照组(P均<0.05);研究组IL-6、TNF-α与IFN-γ水平明显高于对照组(P均<0.05);惊厥发作次数≥2次组及发作持续时间逸5 min组患儿IL-6、TNF-α与IFN-γ水平明显高于惊厥发作<2次组和发作持续时间<5 min组患儿水平(P均<0.05),而CD3+细胞计数、CD4+细胞计数、CD4+/CD8+值明显低于惊厥发作<2次组及发作持续时间<5 min组患儿(P均<0.05);惊厥发作次数和惊厥发作持续时间均与CD3+细胞、CD4+细胞、CD4+ /CD8+值呈负相关(P均<0.05),而与IL-6水平呈正相关(P均<0.05),与TNF-α、IFN-γ水平无相关性(P均>0.05)。结论:胃肠炎伴良性惊厥患儿发病急性期存在免疫功能紊乱,IL-6和T淋巴细胞可能参与了儿童胃肠炎伴良性惊厥的发病过程。 |
| 关键词: T 淋巴细胞 炎症因子 胃肠炎伴良性惊厥 相关性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.09.001 |
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| 基金项目:清远市科技计划医疗卫生领域自筹经费项目,编号2013B066。 |
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| Correlation between T Lymphocytes, Serum Inflammatory Factors and Gastroenteritis with Benign Convulsions |
| Lu Lingli, Zhang Weifeng, Chen Hualin |
| (Qingyuan City Maternal and Child Health Care Center, Guangdong Qingyuan 511500, China) |
| Abstract: |
| Objective: To investigate the correlation between T lymphocytes, serum inflammatory factors and gastroenteritis with benign convulsions. Methods: Thirty six children of gastroenteritis with benign convulsions who treated in our hospital from January 2013 to August 2015 were selected as the study group, and 25 healthy children were selected as the control group. The levels of T lymphocytes(including CD3+ ,CD4+ and CD4+ /CD8+) and serum inflammatory factors (including IL-6, TNF-α and IFN-γ) were examined by McAb-APAAP method and chemiluminescence method, then the differences were compared between the study group and the control group. The correlations between the frequency and duration of seizure in children with gastroenteritis complicated with benign convulsions and these indexes were analyzed. Results: The CD3+ , CD4+ , CD4+ /CD8+ values in the study group were lower than those in the control group (all P<0.05). The IL-6, TNF-α and IFN-γ levels in the study group were significantly higher than those in the control group (all P<0.05). The IL-6, TNF-α and IFN-γ levels in the frequency of seizure more than or equal to 2 times group and the duration of seizure more than or equal to 5 min group were significantly higher than those in the frequency of seizure less than 2 times group and the duration of seizure less than 5 min group (all P<0. 05), while the CD3+ , CD4+ , CD4+ / CD8+ values were obviously lower than those in the frequency of seizure less than 2 times group and the duration of seizure less than 5 min group (all P<0.05). The frequency and duration of seizure were significantly negatively related to the CD3+ , CD4+ , CD4+ / CD8+ values respectively (all P<0.05), significantly positively related to the IL-6 level (both P<0.05), without significant correlations with the TNF-α and IFN-γ levels (all P>0.05).Conclusion: The incidence of gastroenteritis with benign convulsions in acute phase exist immune function disorder, and the cytokine IL-6 and T lymphocytes may be involved in the pathogenesis of gastroenteritis with benign convulsions. |
| Key words: T lymphocytes inflammatory factors gastroenteritis with benign convulsions correlation |
