| 摘要: |
| 目的:探讨阿片类药物对行机械通气新生儿疼痛程度、生命体征及远期神经功能发育的影响。方法:选取我院2010年1月至2014年11月收治的行机械通气新生儿135例,按照随机区组法分为对照组68例和试验组67例,排除死亡和失访病例,实际纳入研究128例,对照组和试验组各64例。两组患儿气管插管后分别给予安慰剂和芬太尼静脉给药,比较两组患儿用药前后新生儿疼痛(PIPP)评分、生命体征指标水平,随访智力发育指数(MDI) 和精神运动发育指数(PDI)。结果:试验组患儿用药后30 min、1 h及2 h PIPP评分均显著低于对照组,差异有统计学意义(P<0.05);两组患儿用药前后平均动脉压和经皮血氧饱和度水平比较差异无统计学意义(P>0.05);试验组患儿用药后30 min、1 h及2 h呼吸频率和心率水平均显著低于对照组,差异有统计学意义(P<0.05);两组患儿随访不同月龄MDI和PDI水平比较差异无统计学意义(P>0.05)。结论:阿片类药物可有效缓解行机械通气新生儿气管插管疼痛,降低心率和呼吸频率,且对远期神经功能发育无不良影响。 |
| 关键词: 阿片类药物 机械通气 新生儿 疼痛 生命体征 神经功能 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.07.005 |
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| 基金项目: |
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| Opioid Drug on Pain, Vital Signs, and Long-Term Development of Neurological Function of Neonates withMechanical Ventilation |
| Liu Gang, Liang Daoqiong, Li Wei, Tang Xuemin, Lai Siyan |
| (The Second People's Hospital of Panzhihua, Sichuan Panzhihua 617068, China) |
| Abstract: |
| Objective: To investigate the effects of opioid drug on pain, vital signs, and long-term development of neurological function of neonates with mechanical ventilation. Methods: One hundred and thirty five neonates with mechanical ventilation were chosen from January 2010 to November 2014 in our hospital and randomly divided into two groups, elminate the death and loss to follow-up cases, 128 cases included in the study, 64 cases in each group. The control group with placedo intravenous adiminstration and the experiment group with fentanyl intravenous adiminstration. The neonatal pain (PIPP) score and the levels of vital signs before and after treatment, mental development index (MDI) and mental motor development index (PDI) of both groups were compared in the follow-up period. Results: The PIPP scores in 30 min, 1 h and 2 h after treatment of experiment group was significantly lower than control group (P<0.05). There were no significant differences in the levels of mean arterial pressure and transcutaneous oxygen saturation before and after treatment between two groups (P>0.05). The levels of respiratory rate and heart rate in 30 min, 1 h and 2 h after treatment of experiment group were significantly lower than control group (P<0.05). There were no significant differences in the levels of MDI and PDI in different month-old with follow-up between two groups (P>0.05). Conclusion: Opioid drug on neonates with mechanical ventilation can efficiently relieve intubation pain, reduce the heart rate and respiratory rate, and has no adverse effect on long-term neurological function. |
| Key words: opioid drug mechanical ventilation neonates pain vital signs neurological function |
