| 摘要: |
| 目的:探讨炎性指标降钙素原(PCT)、白细胞介素12(IL-12)、超敏C反应蛋白(hs-CRP)在新生儿感染性疾病早期诊断中的应用价值。方法:选取我院收治的73例新生儿感染患儿,根据其病情严重程度分为重症组40例和轻症组33例,同时选取我院同期收治的30例非感染性疾病新生儿作为对照组,采用双抗体夹心法测定所有患儿血清PCT 水平,酶联免疫吸附法测定IL-12水平,免疫比浊法测定hs-CRP水平。结果:感染组治疗前血清PCT、IL-12 及hs-CRP水平均明显高于恢复期(t分别为6.293、5.294、3.199,P<0.05),感染组恢复期与对照组比较差异无统计学意义(t分别为0.968、1.037、0.548, P>0.05)。重症感染组PCT、IL-12及hs-CRP水平均明显高于轻症感染组(t分别为5.559、4.376、3.927, P<0.05),轻症感染组三项指标均明显高于对照组(t分别为6.627、5.937、3.839, P<0.05)。单独检测时,以PCT的敏感性及特异性最高,联合检测PCT+IL-12+hs-CRP对于诊断新生儿败血症的特异性最高,组间比较差异有统计学意义(P<0.05)。结论:联合检测PCT、IL-12及hs-CRP能够明显提高对新生儿感染性疾病的临床诊断准确性,为临床工作提供早期的诊断依据。 |
| 关键词: 新生儿感染 炎性因子 临床价值 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.10.002 |
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| 基金项目: |
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| Early Diagnosis Significance of Cytokine in Neonatal Infectious Diseases |
| Yu Xinqiao, Zhang Yongfang |
| (Enshi Tujia and Miao Autonomous Prefecture Central Hospital, Hubei Enshi 445000, China) |
| Abstract: |
| Objective: To explore the application value of procalcitonin (PCT), interleukin 12 (IL-12) and high-sensitivity C reactive protein (hs-CRP) in early diagnosis of neonatal infectious diseases. Methods: A total of 73 newborns with infection treated in our hospital, were divided into severe group (40 cases) and mild group (33 cases) according to the severity, and 30 newborns with non infectious diseases were selected as control group who treated in our hospital. Then we used double antibody sandwich method to detect PCT levels in two groups, enzyme linked immunosorbent assay was used to detect levels of IL-12, immune turbidimetric method was used to detect levels of hs-CRP. Results: Before treatment, three indexes of severe group and mild group were significantly higher than those in convalescent period (P<0.05), the indexes of infection group in the recovery stage and control group had no significant difference, three indexes of severe group were significantly higher than those in mild group ( P<0.05), three indexes of mild group were significantly higher than those in the control group. When we used a single index, PCT has the highest sensitivity and specificity, the joint detection indexes of PCT, IL-2 and hs-CRP had the highest specificity in neonatal sepsis (P<0.05). Conclusion: The joint detection indexes of PCT, IL-2 and hs-CRP can significantly improve the accuracy of clinical diagnosis of neonatal infectious diseases, and provide early diagnostic basis for clinical work. |
| Key words: neonatal infection inflammatory factor clinical value |
