| 摘要: |
| 目的:分析我院2015年药品不良反应(ADR)监测情况,为临床安全、合理用药提供参考。方法:采用回顾性研究方法,分类统计我院2015年收集的123例ADR报告,分别从患儿的一般资料、给药途径、药品种类、ADR累及的系统或器官、主要临床表现等方面进行统计分析。结果:123例ADR中,0 ~3岁患儿比例最高,为54.47% (67例);与抗感染药物有关的80例,占68.04%,其中万古霉素16例;与抗肿瘤药物有关的18例,其中门冬酰胺酶14例;ADR累及的系统或器官主要为皮肤及其附件系统(93例,75.61%)。结论:医院应加强儿童ADR的监测及相关知识的宣传,合理使用抗菌药物,减少静脉注射频率,以保障用药安全。 |
| 关键词: 儿童 药品不良反应 合理用药 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.09.013 |
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| 基金项目: |
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| Adverse Drug Reaction of Children in Our Hospital: 123 Reports |
| Yu Chunling, Cheng Hua |
| (Xi'an Children's Hospital, Shaanxi Xi'an 710003, China) |
| Abstract: |
| Objective: To summarize the results of adverse drug reaction (ADR) supervision in our hospital in 2015 in order to improve rational and safe clinical drug treatment for children. Methods: In the retrospective statistical analysis study, a total of 123 ADR reports in 2015 were analyzed and evaluated in respects of patients’ basic conditions, route of administration, drug varieties, involved organs and systems, and clinical manifestations. Results: Of the total 123 ADR reports, children between 0 and 3 years were the highest proportion (67 cases, 54.47%), there were 80 cases relating to the use of anti-infective drugs, taking up 68.04%, in which there were 14 cases relating to vancomycin. There were 18 cases relating to the use of antineoplastic drugs, in which there were 14 cases relating to the use of asparaginase. The major organ-system damages involved in ADR were skin and appendages disorders (93 cases, 75.61%). Conclusion: In order to insure the safety of drug usage in children, we should strengthen the monitoring and publicize of ADR knowledge, use the antimicrobial agents rationally, reduce the frequency of intravenous administration. |
| Key words: children adverse drug reaction rational use of drug |
