| 摘要: |
| 目的:观察脾氨肽辅助治疗儿童抗生素相关性腹泻的效果及其对小儿免疫功能的影响,为临床提供新治疗途径。方法:选取我院2012-2014年收治的小儿抗生素相关性腹泻患儿120例为研究对象,按照随机数表法将其分为实验组和常规组各60例。常规组给予一般方法治疗,主要为止泻、抗感染、微生态药物(酪酸梭菌肠球菌三联活菌片)及支持治疗等,实验组在一般治疗的基础上加脾氨肽冻干粉治疗,每次2 mg,凉开水溶解后服用,每日1次,疗程均为14 d。两组均于治疗前、后采集空腹血,采用流式细胞检测仪检测T淋巴细胞亚群(CD4+/CD8+、CD8+、CD4+、CD3+) 的变化,采用单向琼脂扩散法检测血免疫球蛋白(IgA、IgG、IgM)水平;评价实验组及常规组患儿抗生素相关性腹泻的临床疗效,观察停药1周后病情复发情况。结果:实验组和常规组患儿呕吐缓解时间、腹泻停止时间及痊愈时间分别为(1.4±0.7) d vs (3.1±1.3) d、(2.8±1.6) d vs (5.6±2.3) d、(7.9±1.7)d vs (10.7±1.8)d,差异有统计学意义(P<0.01);实验组临床总有效率93.3%,高于常规组的76.7%(P<0.05);实验组复发率5.00%,低于常规组的20.00%( P<0.05);两组患儿治疗后血清免疫球蛋白IgG、IgA和T淋巴细胞亚群CD3+ 、CD4+、CD4+ /CD8+水平较治疗前均明显升高(P<0.05)。结论:小儿抗生素相关性腹泻在一般治疗基础上加用脾氨肽冻干粉治疗,对于肠道微生态平衡的重建有益,同时能够抑制病原菌生长,增强患儿的免疫功能,提高疗效,减少复发,值得临床推广。 |
| 关键词: 抗生素相关性腹泻 脾氨肽 酪酸梭菌肠球菌三联活菌 免疫功能 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.10.011 |
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| 基金项目: |
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| The Effect of Spleen Aminopeptide in Children with Antibiotic-Associated Diarrhea |
| Xu Liyun |
| (Shandong Medical College, Linyi People's Hospital of Shandong, Shandong Linyi 276003, China) |
| Abstract: |
| Objective: To observe the effect of spleen aminopeptide on antibiotic-associated diarrhea in children and observe the influence on children’s immune functions so as to offer some new clinical therapy. Methods: One hundred and twenty children with antibiotic-associated diarrhea treated in our hospital from 2012 to 2014 were randomly divided into the experimental group and the routine treatment group, with 60 cases in each group. The routine treatment group was received conventional therapy including antidiarrheic therapy, anti-infection therapy, microecological drugs (enterococcus butyric acid bacteria sanlian living bacterium) and supporting therapy. The experimental group was received 2 mg of spleen aminopeptide once a day for 14 days as a course of treatment in addition to the routine treatment. The detection of the levels of fasting blood glucose, the changes in the levels of CD4+/CD8+, CD8+, CD4+, and CD3+ and the levels of IgA, IgG and IgM were conducted. The detection results were used to evaluate the effect of spleen aminopeptide in children with antibiotic-associated diarrhea and its influence on children’s immune functions. The recurrence rates of antibiotic-associated diarrhea of the two groups were also analyzed. Results: The time of vomiting relief, diarrhea stoped and cure in experimental group and routine treatment group were (1.4±0.7) d vs (3.1±1.3) d, (2.8±1.6) d vs (5.6±2.3) d, (7.9±1.7)d vs (10.7±1.8)d, and the differences had statistical significance (P<0.05). The total effective rate in experimental group was 93.3%, in routine treatment group was 76.7%(P<0.05). The levels of CD4+ / CD8+, CD8+, CD4+ and CD3+ and the levels of IgG and IgA all increased more significantly in both groups than before treatment (P<0.05). Conclusion: The combined use of spleen aminopeptide and the routine therapy can reconstruct intestinal microecological balance and can inhibit the growth of pathogenic bacteria and reduce the recurrence. |
| Key words: antibiotic-associated diarrhea spleen aminopeptid enterococcus butyric acid bacteria sanlian living bacterium immune function |
