| 摘要: |
| 目的:比较两种不同维持剂量枸橼酸咖啡因防治早产儿呼吸暂停的疗效。方法:选择2014年1月至2015年8月在北京大学深圳医院住院且胎龄臆32周的原发性呼吸暂停早产儿72例,随机分为A组[枸橼酸咖啡因维持量为20 mg/(kg·d)] 和B组[枸橼酸咖啡因维持量为10 mg/(kg·d)] 各36例,比较两组呼吸暂停频率及辅助通气情况,观察患儿支气管肺发育不良、坏死性小肠结肠炎、早产儿视网膜病及严重脑室内出血等并发症发生情况及药物相关不良反应。结果:A组在呼吸暂停时间及氧疗时间均短于B组(P<0.05);两组nCPAP辅助通气时间及拔管后重新插管例数比较差异无统计学意义(P>0.05);两组主要不良反应(心动过速、喂养不耐受、体质量增加时间)比较差异均无统计学意义(P>0.05);A组患儿恢复出生体质量时间长于B组(P<0.05);两组主要并发症发生率比较差异无统计学意义(P>0.05)。结论:20 mg/(kg·d) 维持剂量咖啡因能改善早产儿呼吸暂停情况且不良反应发生率未明显增加,但是否为最优剂量仍需进一步研究。 |
| 关键词: 枸橼酸咖啡因 早产儿 呼吸暂停 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2016.09.005 |
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| 基金项目: |
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| Effect of Different Maintenance Doses Caffeine for Apnea of Preterm |
| Xu Songzhou, Hu Xiaoyan, Zhao Fang, Zhou Yuxing, Zhang Shuangchuan |
| (Peking University Shenzhen Hospital, Guangdong Shenzhen 518036, China) |
| Abstract: |
| Objective: To compare the efficacy of two different doses of caffeine citrate on apnea of preterm (AOP). Methods: A total of 72 preterm infants ≤ 32 weeks gestation (36 in each group) with apnea were enrolled, and divided into group A with high maintenance dose (20 mg/ (kg·d)) and group B with low maintenance dose (10 mg/(kg·d)) caffeine citrate. Apnea frequency and assisted ventilation of two groups were observed. Bronchopulmonary dysplasia, necrotizing enterocolitis, retinopathy of premature, severe cerebral hemorrhage and adverse drug reactions of two groups were observed. Results: The apnea time and oxygen therapy time of group A was shorter than those of group B (P<0.05). There were no statistical differences in nCPAP ventilation time and rate of reintubation after extubation between two groups (P>0.05). The major adverse reactions (tachycardia, feeding intolerance, average weight growth) of two groups had no statistical differences (P>0.05). The recovering to birth weight time of group A was longer than that of group B (P<0.05). The main complications occurrence rates of two groups had no differences (P>0.05). Conclusion: Caffeine with a dose of 20 mg/(kg·d) can improve the symptoms of apnea in preterm and the incidence of adverse reaction is not significantly increased, but the optimum caffeine dose in preterm infants need to be well investigated. |
| Key words: caffeine citrate preterm apnea |
