| 摘要: |
| 目的:探讨头部亚低温治疗对新生儿缺氧缺血性脑病(HIE)脑脊液中肌酸激酶脑型同工酶(CK鄄BB)的影响及临床治疗效果。 方法:选择 2014 年 3 月至 2016 年 3 月在我院治疗的 HIE 患儿 84 例,随机分为亚低温组 39 例和常规治疗组 45 例,亚低温组在常规治疗基础上给予头部亚低温治疗,常规治疗组给予 HIE 常规治疗,检测两组患儿脑脊液中 CK鄄BB 变化,同时进行新生儿神经行为(NBNA)评分和婴幼儿期智能发育评估。 结果:亚低温组和常规治疗组患儿治疗 72 h 后脑脊液中 CK鄄BB 较治疗前降低(P<0.05);亚低温组治疗72 h 后脑脊液中 CK-BB 为(13.10±1.57)U/ L,明显低于常规治疗组(P<0.05);两组出生14 d、28 d 时 NBNA 评分均较出生 7 d 时明显升高(P<0.05);亚低温组出生14 d 和28 d 时 NBNA 评分为(37.10±1.32)分和(38.10±1.30)分,均明显高于常规治疗组(P<0.05);亚低温组出生后 3 个月和 6 个月智力发育指数(MDI)分别为(91.02±9.80)分和(99.10±7.53)分,明显高于常规治疗组(P<0.05);亚低温组出生后 3 个月和 6 个月心理运动发育指数(PDI)分别为(87.22±6.72)分和(95.10±5.52)分,明显高于常规治疗组(P<0.05)。 结论:头部亚低温治疗 HIE 有较好的效果,能明显降低患儿脑脊液中 CK-BB 水平,值得临床推广。 |
| 关键词: 头部亚低温 缺氧缺血性脑病 肌酸激酶脑型同工酶 脑脊液 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2018.05.006 |
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| 基金项目: |
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| Head Mild Hypothermia on Creatine Kinase Brain Band Isoenzyme in Cerebrospinal Fluid of Children with Hypoxic Ischemic Encephalopathy and Its Clinical Therapeutic Effect |
| Lan Delian |
| (The Second People's Hospital of Neijiang, Sichuan Neijiang 641100, China) |
| Abstract: |
| Objective: To investigate effects of head mild hypothermia on creatine kinase brain band isoenzyme ( CK-BB) in cerebrospinal fluid of neonates with hypoxic ischemic encephalopathy (HIE) and its clinical therapeutic effect. Methods: Selected 84 children with HIE in our hospital from March 2014 to March 2016, which were randomly divided into mild hypothermia group (n=39) and conventional treatment group (n=45). The mild hypothermia group was given head mild hypothermia on the basis of conventional treatment, routine treatment group was given HIE conventional treatment. The changes of CK-BB in cerebrospinal fluid were detected,and evaluated the neonatal neurobehavioral (NBNA) score and infant intelligence development were evaluated in two groups. Results: Cerebrospinal fluid CK-BB in two groups after the treatment of 72 h was decreased (P<0.05). Cerebrospinal fluid CK-BB in mild hypothermia group after the treatment of 72 h was (13.10±1.57) U/ L, significantly lower than the conventional treatment group (P<0.05). All children in two groups born 14 d, 28 d NBNA scores were higher than born 7 d significantly (P<0.05).NBNA scores were (37.10±1.32) and (38.10±1.30) in mild hypothermia group born 14 d and 28 d, were significantly higher than those of the conventional treatment group (P<0.05). The mental development index (MDI) of the mild hypothermia group at 3 and 6 months after birth were (91.02±9.80) and (99.10±7.53), significantly higher than those of the conventional treatment group (P<0.05).The indexes of psychomotor development (PDI) of the mild hypothermia group at 3 and 6 months after birth were (87.22±6.72) and (95.10±5.52), significantly higher than those of the conventional treatment group (P<0.05). Conclusion: Head mild hypothermia treatment of HIE has a better effect, and significantly reduce the level of CK-BB in cerebrospinal fluid, worthy of clinical promotion. |
| Key words: head mild hypothermia hypoxic ischemic encephalopathy creatine kinase brain band isoenzyme cerebrospinal fluid |
