| 摘要: |
| 目的:观察阿立哌唑对儿童Tourette综合征患儿血清细胞因子水平的影响及疗效。方法:选取88例儿童Tourette综合征患儿,随机分为试验组和对照组。对照组患儿予以口服氟哌啶醇治疗,先给予1.0 mg/d,每周加量1次,至症状消失或达最大剂量6.0 mg/d。试验组予以口服阿立哌唑治疗,先给予2.5 mg/d,每周加量1次,至症状消失或达最大剂量10.0 mg/d。两组患儿均连用≥8周。观察两组患儿治疗前和治疗8周后血清IL-6、IL-8 和TNF-α水平的变化,并采用YGTSS评分和不良反应量表(TESS)于治疗结束后评定疗效和不良反应。结果:试验组和对照组患儿治疗中分别失访3例和5例,两组失访率比较差异无统计学意义(χ2=0.50,P>0.05)。治疗8周后,两组患儿血清IL-6、IL-8水平较前明显上升,TNF-α水平较前明显下降(P<0.05),且试验组患儿变化幅度较对照组更大(P<0.05);同时试验组患儿临床总有效率92.68%,高于对照组的76.32%,(χ2=4.07,P<0.05)。采用TESS评分评定药物不良反应,试验组患儿不良反应发生率低于对照组(χ2=4.39,P<0.05)。结论:阿立哌唑治疗儿童Tourette综合征临床效果及安全性均明显优于氟哌啶醇,其作用机制可能与其能通过升高血清IL-6、IL-8 和降低血清TNF-α水平,提高其免疫功能及抑制炎症反应密切相关。 |
| 关键词: Tourette 综合征 儿童 阿立哌唑 氟哌啶醇 细胞因子 |
| DOI：doi: 10.13407/j.cnki.jpp.1672-108X.2017.12.008 |
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| 基金项目: |
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| Curative Effect and Influence of Aripiprazole on Serum Cells Factors Levels of Children with Tourette Syndrome |
| Weng Weiqi 1, Hu Wenhui 2 |
| (1. Taizhou Cancer Hospital of Zhejiang Province, Zhejiang Taizhou 317502, China; 2. Taizhou People's Hospital, Zhejiang Taizhou 317000, China) |
| Abstract: |
| Objective: To observe the influence and curative effect of aripiprazole on serum cells factors levels of children with Tourette syndrome. Methods: Eighty-eight cases of children with Tourette syndrome were selected, and divided into experimental group and control group at random. The children in control group were given oral haloperidol from the beginning of 1.0 mg/d until the disappear of symptom or the max dose of 6.0 mg/d with once adding weekly, while the children in experimental group were given oral aripiprazole from the beginning of 2.5 mg/d until the disappear of symptom or the max dose of 10.0 mg/d with once adding weekly for 8 or more than 8 weeks. The changes of serum IL-6 and IL-8 and TNF-α levels of children in two groups were observed before and 8 weeks after medical treatment, and curative effect and adverse reactions were evaluated in accordance with YGTSS score and treatment emergent symptom scale (TESS) after medical treatment. Results: Three and five cases of loss to follow up were appeared on children in experimental group and control group respectively during treatment respectively, and after comparing the loss rates to follow up of children in two
groups, no statistical difference was appeared (χ2=0.50, P>0.05). After 8 weeks' treatment, serum IL-6 and IL-8 levels in two groups were obviously increased than before, and TNF-α levels in two groups were obviously decreased than before (P<0.05), and the rising rates of children in experimental group were much higher than those in control group (P<0.05). Meanwhile, the total clinical efficiency of children in experimental group (92.68%) was much higher than that in control group (76.32%, χ2=4.07, P<0.05).
The incidence of adverse reaction of children in experimental group was much lower than that in control group (χ2=4.39, P<0.05) in accordance with TESS. Conclusion: Compared with haloperidol, aripiprazole has more favorable clinical curative effect and security in children with Tourette syndrome, whose mechanism of action may have close effect on raising serum IL-6 and IL-8 and decreasing serum TNF-α level to improve immune function and inhibit inflammatory response. |
| Key words: Tourette syndrome children aripiprazole haloperidol cell factors |
