| 摘要: |
| 目的:分析腹型过敏性紫癜(HSP)患儿治疗过程中使用丙种球蛋白进行冲击治疗的临床效果。方法:将52例腹型HSP患儿随机分为甲泼尼龙组28例和丙种球蛋白组24例。甲泼尼龙组患儿采用甲泼尼龙和常规治疗方法进行治疗;丙种球蛋白组患儿在常规治疗基础上,给予丙种球蛋白冲击治疗,观察两组患儿的临床疗效和复发率。结果:丙种球蛋白组患儿皮疹完全消退时间、腹痛缓解时间、呕吐缓解时间、血便消失时间及住院时间短于甲泼尼龙组,差异有统计学意义(P<0.01);丙种球蛋白组的有效率为92.86%,高于甲泼尼龙组的83.33%,但差异无统计学意义(P>0.05);随访至3个月和6个月,甲泼尼龙组患儿的复发率均高于丙种球蛋白组,但差异无统计学意义(P>0.05);甲泼尼龙组患儿不良反应发生率(33.33%)高于丙种球蛋白组(3.57%)。结论:丙种球蛋白冲击治疗腹型HSP有较好的效果,复发率低,不良反应发生率较低。 |
| 关键词: 过敏性紫癜 丙种球蛋白 儿童 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.07.008 |
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| 基金项目: |
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| Gamma Globulin of Pulse Therapy for Children with Henoch-Schönlein Purpura |
| Luo Yahui1 , Liao Zhixiong2 |
| (1. Hubei Hanchuan People's Hospital, Hubei Hanchuan 431600, China; 2. Hanchuan Traditional Chinese Medical Hospital, Hubei Hanchuan 431600, China) |
| Abstract: |
| Objective: To analyze the clinical effects of gamma globulin of pulse therapy for children with Henoch-Schönlein purpura (HSP). Methods: Fifty two children with peritoneal HSP were randomly divided into methylprednisolone group (n=28) and gamma globulin group (n=24). Patients in methylprednisolone group were treated with methylprednisolone and conventional therapy; while patients in gamma globulin group received a certain dose of gamma globulin on the basis of conventional therapy. The clinical efficacy and recurrence rate of two groups were observed. Results: The total disappearance time of rash, relief time of abdominal pain and vomiting, disappearance time of bloody stool and length of stay were significantly shorter in the gamma globulin group than in the methylprednisolone group, the difference was statistically significant (P<0.01). The effective rate of gamma globulin group was 92.86%, higher than that of methylprednisolone group 83.33%, but there was no statistically significant difference (P>0.05). After follow-up for 3 months and 6 months, the recurrence rate of children in the methylprednisolone group was higher than that in methylprednisolone group, without any statistically significant difference (P>0.05). The incidence of adverse drug reactions of methylprednisolone group (33.33%) was higher than that of gamma globulin group (3.57%). Conclusion: The effect of gamma globulin of pulse therapy for children with HSP is significant, with lower recurrence rate and incidence of adverse drug reactions. |
| Key words: Henoch-Sch?nlein purpura gamma globulin children |
