| 摘要: |
| 目的:评价氨己烯酸治疗婴儿痉挛的疗效和安全性。方法:选择2015年4月至2016年9月于韩国Severance儿童医院诊治的46例婴儿痉挛患者给予口服氨己烯酸治疗,起始剂量为50mg/(kg·d),第2天加至100mg/(kg·d),如症状控制明显,则继续应用3~6个月,定期复查脑电图;如1周后无效,则加量至150mg/(kg·d),应用3~6个月,随访时间为3~10个月。结果:氨己烯酸单药治疗总有效率为67.4%(31/46),无发作率为19.6%(9/46),复发率6.5%(3/46),短期不良反应主要为嗜睡、纳差、激惹、多动。结论:氨己烯酸治疗婴儿痉挛症效果显著,复发率低,不良反应通常在早期出现。 |
| 关键词: 婴儿痉挛 氨己烯酸 疗效 安全性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.07.002 |
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| 基金项目: |
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| Efficacy and Safety of Vigabatrin in the Treatment of Infantile Spasms |
| Nan Zaiyuan1, Cho Minjung2, A-Ra Ko2, Kang Hoonchul2 |
| (1. Children's Hospital of Harbin, Second Afficiated Hospital of Harbin Medical University, Heilongjiang Harbin 150010, China; 2. Severance Children's Hospital, College of Medicine, Yonsei University, Seoul, Republic of Korea)) |
| Abstract: |
| Objective: To evaluate the efficacy and safety of vigabatrin(VGB) in the treatment of infantile spasms(IS). Methods:
Forty-six IS patients admitted into Severance Children's Hospital from April 2015 to Sept. 2016 were given oral VGB at an initial dose
of 50 mg/(kg·d), the next day added to 100 mg/(kg·d); if the symptom control was significant, the application would be continued
for 3~6 months, and the regular review of EEG was conducted. If it was not effective after 1 week, the dosage would be added to
150 mg/(kg·d), with application of 3~6 months and followed up for 3~10 months. Results: The total effective rate of monotherapy
of VGB was 67.4%(31/46), the seizure free was 19.6%(9/46) and the relapse rate was 6.5%(3/46). Short-term adverse drug
reactions were mainly performed as drowsiness, anorexia, irritability and hyperactivity. Conclusion: The effects of VGB in the treatment
of IS is significant, and the relapse rate is low with the side-effects usually appearing early. |
| Key words: infantile spasms vigabatrin efficacy safety |
