| 摘要: |
| [摘要] 目的:探讨手足口病患儿体内Ghrelin 水平与 TNF-α、IL-1β、IL-6水平的相关性。 方法:选择 2015-2016 年于我院儿科就诊的手足口病患儿(研究组)和在体检中心进行体检的健康儿童(对照组)各100 例,研究组患儿根据病情分为轻症组(无脑炎)68 例和重症组(有脑炎)32 例。 采用酶联免疫吸附试验(ELISA)法测定三组儿童外周血中 Ghrelin 的含量,同时采用化学发光 分析仪测定外周血中免疫细胞因子TNF-α、IL-1β、IL-6水平,分析手足口病患儿 Ghrelin 水平与 TNF-α、IL-1β、IL-6水平的相关性。 结果:Ghrelin 水平重症组<轻症组<对照组(P 均<0.05);IL-6、IL-1β、TNF-α水平重症组>轻症组>对照组(P 均<0.05);手 足口病患儿外周血
Ghrelin 水平与 TNF-α、IL-1β、IL-6 均呈负相关(r 分别为-0.31、-0.33、-0.29,P 均<0.05)。 结论:Ghrelin 可能对手足口病的炎症免疫反应起保护作用,
Ghrelin 可以作为预测手足口病预后的指标之一。 |
| 关键词: Ghrelin 手足口病 TNF-α IL-1β IL-6 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.03.001 |
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| 基金项目:广西壮族自治区卫生和计划生育委员会自筹经费科研课题,编号 Z2015103。 |
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| Relevance of TNF-α、IL-1β、IL-6and Ghrelin in Children with Hand, Foot and Mouth Disease |
| Feng Haiying, Huang Bo, Li Bai, Liang Qing, Liao Suwen, Ma Qiaorong, Liang Ying |
| (Minzu Hospital of Guangxi Zhuang Autonomous Region,Guangxi Nanning 530001, China) |
| Abstract: |
| [Abstract] Objective: To investigate the relevance of TNF-α,IL-1β,IL-6and Ghrelin Levels in children with hand, foot and mouth
disease.Methods: Children with hand, foot and mouth disease (study group) and the healthy children from the health center (control
group) with 100 cases in each from 2015 to 2016 of our hospital were chosen. According to the severity of illness, study group were
divided into mild group (without encephalitis) and severe group (with encephalitis). ELISA method was used to determine the content
of three groups of children in the peripheral blood of Ghrelin, while chemiluminescence analyzer was used to determine [Keywords] Ghrelin; hand, foot and mouth disease; TNF-α, IL-1β, IL-6 levels in peripheral blood of immune cells, and the correlation of Ghrelin and TNF-α、IL-1β、IL-6 levels were analyzed.Results:
The Ghrelin level of severe group was lower than that of mild group, and the mild group was lower than that of control group, while 、IL-6,IL-1β,TNF-αlevels of severe group were higher than mild group, and the mild group were higher than those of control group (P<0.05).
The levels of Ghrelin in peripheral blood of children with hand, foot and mouth disease were negatively correlated with TNF-α,IL-1βandIL-6(r = -0.31,-0.33,-0. 29, respectively, P<0.05). Conclusion: Ghrelin may protect immune response inflammation of hand,
foot and mouth disease.It can become a predicting prognosis factor. |
| Key words: Ghrelin hand, foot and mouth disease TNF-α IL-1β IL-6 |
