| 摘要: |
| [摘要]目的：通过比较正常儿童与抽动障碍（TD）患儿T淋巴细胞亚群的差异，探究TD患儿发病及病情严重程度与T淋巴细胞亚群之间的关系，并探索TD在细胞免疫方面可能存在的发病机制。方法：采用流式细胞仪技术测定53例TD患儿及30例健康体检儿童T淋巴细胞亚群水平，并进行比较。结果：TD组CD8+水平较对照组显著升高，CD4+及CD4+/CD8+水平均低于对照组（P均<0.05）；CD3+水平与对照组比较差异无统计学意义（P>0.05）。TD患儿的YGTSS评分、发病时间长短及病情严重程度与T淋巴细胞亚群水平均之间没有明显的对应关系。结论：TD患儿的发病与细胞免疫相关，且CD8+T淋巴细胞在其中起主导作用，但未见其与TD的病程长短及严重程度具有相关性。 |
| 关键词: 抽动障碍 T淋巴细胞亚群 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.06.001 |
|
| 基金项目: |
|
| Changes of T Lymphocyte Subsets in Tic Disorders Children |
| Wang Qiong1, Wang Guoliang2, Han Fei3, Fan Fei3, Yang Zhenyu3 |
| (1. Xi’an Children’s Hospital, Shaanxi Xi’an 710003, China; 2. Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China; 3. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China) |
| Abstract: |
| [Abstract] Objective: To investigate the connection between the causes, onset time, severity of Tic Disorders (TD) and the T lymphocyte subsets levels of TD children, and to explore the existential pathogenesis in cellular immunity of TD through comparing the differences of T lymphocyte subsets levels of TD children with normal children. Methods: Flow cytometry was adopted to determine and compare the T lymphocyte subsets levels of TD group (n=53) and control group (n=30). Results: Compared with the control group, the CD8+ T cells level of TD group increased significantly; yet the CD4+, the CD4+/CD8+ T cells levels of TD group were lower than those of the control group (P<0.05); and the CD3+ T cells of TD group was lower than that of the control group, the difference was not statistically significant (P>0.05). Meanwhile, there was no significant correspondence between the YGTSS score, onset time, severity of TD and T lymphocyte subsets levels. Conclusion: The onset time of TD children is correlated with cellular immunity, which is on the basis of the CD8+ T cells’ leading role, yet it has nothing to do with the onset time and the severity of TD. |
| Key words: tic disorders T lymphocyte subsets |
