| 摘要: |
| 目的:进一步研究小儿速效感冒颗粒中对乙酰氨基酚、马来酸氯苯那敏及咖啡因的含量测定方法。方法:采用高效液相色谱(HPLC)梯度洗脱法同时测定小儿速效感冒颗粒中对乙酰氨基酚、马来酸氯苯那敏及咖啡因的含量。结果:在268 nm波长下,三种成分均具有较好的响应值,线性关系良好。结论:本方法同时测定小儿速效感冒颗粒中对乙酰氨基酚、咖啡因和马来酸氯苯那敏的含量,是专属、准确、可行的。 |
| 关键词: 小儿速效感冒颗粒 高效液相色谱法 含量测定 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.07.015 |
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| 基金项目: |
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| Improvement of Determination Method for Effective Components in Xiao'er Suxiao Ganmao Granules |
| Han Lin1 , Wang Qingxue2 , Shi Qinyi1 |
| (1. Xuzhou Children's Hospital Affiliated to Xuzhou Medical University, Jiangsu Xuzhou 221006, China; 2. Xuzhou Social Welfare Homes, Jiangsu Xuzhou 221006, China) |
| Abstract: |
| Objective: To further establish a method for determination of paracetamol, caffeine and chlorphenamine maleate in Xiao’er Suxiao Ganmao granules. Methods: Contents of paracetamol, caffeine and chlorphenamine maleate in Xiao’er Suxiao Ganmao granules were simultaneously determined by high performance liquid chromatography (HPLC) gradient elution. Results: At 268 nm wavelength, all three components had good response values with good linearity. Conclusion: This method is specific, accurate, and feasible for simultaneous determination of paracetamol, caffeine and chlorphenamine maleate in Xiao’er Suxiao Ganmao granules. |
| Key words: Xiao'er Suxiao Ganmao granules HPLC determination of content |
