| 摘要: |
| 目的:探讨布地奈德联合肺表面活性物质(PS)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效。方法:将我院新生儿科2016年1月至2017年1月收治的96例NRDS患儿,采用随机数字表法分为观察组和对照组各48例。对照组给予PS制剂猪肺磷脂注射液200 mg/kg气管内滴入治疗,观察组给予布地奈德混悬液(0.25 mg/kg)与猪肺磷脂注射液(200 mg/kg)混合后气管内滴入,比较两组患儿在治疗后48 h的临床疗效。结果:观察组总有效率87.5%,对照组总有效率75.0%,两组比较差异有统计学意义(P<0.05)。结论:布地奈德混悬液联合猪肺磷脂注射液治疗NRDS较单用猪肺磷脂注射液疗效更为显著。 |
| 关键词: 布地奈德 肺表面活性物质 新生儿 呼吸窘迫综合征 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.09.006 |
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| 基金项目: |
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| Budesonide Combined with Pulmonary Surfactant in the Treatment of Neonatal Respiratory Distress Syndrome |
| Zhao Jinzhang, Liu Ling |
| (Northwest Women and Children's Hospital, Shaanxi Xi'an 710061, China) |
| Abstract: |
| Objective: To investigate the clinical efficacy of budesonide combined with pulmonary surfactant (PS) in the treatment of neonatal respiratory distress syndrome (NRDS). Methods: Ninety-six children with NRDS from Newborn Department of our hospital from Jan. 2016 to Jan. 2017 were extracted to be divided into observation group and control group via the random number table, with 48 cases in each group. The control group was given poractant alfa injection of 200 mg/kg in intratracheal instillation therapy, while the observation group received intratracheal instillation of budesonide (0.25 mg/kg) mixed with poractant alfa injection (200 mg/kg). The clinical efficacy of two groups was compared within the specified time. Results: The total effective rate of observation group and control group were respectively 87.5% and 75.0%, the difference was statistically significant (P<0.05). Conclusion: Liquid budesonide combined with poractant alfa injection is more effective than poractant alfa injection alone in the treatment of NRDS. |
| Key words: budesonide pulmonary surfactant neonatal respiratory distress syndrome |
