| 摘要: |
| 目的:考察酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液在0.9%氯化钠注射液中的配伍稳定性。方法:采用HPLC法测定配伍液中三种药物含量,考察三种药物在0.9%氯化钠注射液中,室温条件下72 h内的含量变化,同时观察与检测外观与pH变化。结果:酒石酸布托啡诺注射液、盐酸曲马多注射液及盐酸昂丹司琼注射液的配伍液在72 h内三种药物含量未见明显变化,配伍液外观澄清,pH值保持稳定。结论:酒石酸布托啡诺、盐酸曲马多及盐酸昂丹司琼在0.9%氯化钠注射液中室温条件下、72 h内保持稳定。 |
| 关键词: 布托啡诺 曲马多 昂丹司琼 配伍 稳定性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.09.010 |
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| 基金项目:湖北省卫生计生科研基金项目,编号WJ2015MB290;十堰市科学技术研究与开发计划项目,编号16Y60。 |
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| Stability of in Vitro Compatibility of Butofenol Tartrate, Tramadol Hydrochloride and Ondansetron Injection |
| Feng Yunxia, Li Peng, Fang Baoxia, Shi Xiaoya, Chen Fuchao |
| (Dongfeng Hospital Affiliated to Hubei University of Medicine, Hubei Shiyan 442008, China) |
| Abstract: |
| Objective: To investigate the compatible stability of butorphanol tartrate, tramadol hydrochloride and ondansetron hydrochloride in 0.9% sodium chloride injection. Methods: HPLC method was adopted to determine the content of 3 drugs in the compatibility solution. The content changes of 3 injections in 0.9% sodium chloride injection at room temperature for 72 hours were investigated, and changes of appearance and pH values were observed and tested. Results: The compatibility of butofenol injection, tramadol hydrochloride injection and ondansetron hydrochloride injection did not change significantly in the content of 3 drugs within 72 hours. The appearance of the compatibility solution was clarified and the pH values remained stable. Conclusion: Butorphanol tartrate injection, tramadol hydrochloride injection and ondansetron hydrochloride injection were stable in 0.9% sodium chloride injection at room temperature for 72 h. |
| Key words: butorphanol tramadol ondansetron compatibility stability |
