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| 对乙酰氨基酚致婴儿肝损伤1 例药学监护并文献复习 |
| 李志玲1,刘婷2,龚小慧1,胡文娟1,刘红霞1,邢文荣1,孙华君1 |
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| (1. 上海市儿童医院,上海交通大学附属儿童医院,上海200062;2. 深圳市儿童医院,广东深圳 518038)) |
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| 摘要: |
| [摘要] 目的:探讨对乙酰氨基酚(
APAP)致婴儿肝损伤的药学监护及有效治疗方法,初步分析 APAP 引起的肝损伤与相关药物 基因的关系。 方法:临床药师进行药学监护,分析
1 例婴儿使用 APAP 混悬滴剂(泰诺林)治疗后出现急性肝损伤的临床资料, 并结合相关文献进行讨论。 结果:该患儿出现肝损伤后,使用还原型谷胱甘肽保肝、血浆置换解毒,最终患儿的肝损伤症状明显 好转。 经过检测药物相关的
HLA 基因,发现 APAP 导致的肝损伤可能与 HLA鄄B*1502 基因阳性有关。 结论:APAP 导致的肝损 伤是临床常见不良反应,患儿用药后应监测肝功能,必要时给予对症治疗。 同时,对出现肝损伤的婴儿应加强检测药物相关基
因,避免不良发应再次发生。 |
| 关键词: 对乙酰氨基酚 肝损伤 药物基因检测 药学监护 婴儿 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.03.011 |
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| 基金项目: |
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| Pharmaceutical Care of One Case of Liver Injury Induced by Acetaminophen in Infant and Literature Review |
| Li Zhiling1, Liu Ting2, Gong Xiaohui1, Hu Wenjuan1, Liu Hongxia1, Xing Wenrong1, Sun Huajun1 |
| (1. Shanghai Children
's Hospital, Children's Hospital of Shanghai Jiaotong University, Shanghai 200062, China; 2. Shenzhen Children爷s Hospital, Guangdong Shenzhen
518038, China) |
| Abstract: |
| [Abstract] Objective: To explore the effective treatments to liver injury induced by acetaminophen in infant and preliminary analyze
the genes related to the drug-induced liver injury. Methods: The clinical data of one infant of acute liver injury induced by
acetaminophen were reviewed retrospectively. Results: Reduced glutathione and plasma exchange were administered to this infant with
liver injury. A good prognosis was observed following these treatments. Besides, liver injury caused by acetaminophen may be associated
with HLA-B*1502. Conclusion: Liver injury induced by acetaminophen is common in clinical practice. The indicators of liver function
should be monitoring when children are treated with acetaminophen. The principal medical treatments for the subsequent symptoms are
necessary as well as genetic testing of acetaminophen. |
| Key words: acetaminophen liver injury drug genetic testing pharmaceutical care infant |
