| 摘要: |
| 目的:通过检测患儿血清C反应蛋白(CRP)、心肌肌钙蛋白玉(cTnI)、S100B蛋白水平及儿童麻醉苏醒期躁动评分(PAED),评价帕瑞昔布钠预防腭裂修补术患儿麻醉苏醒期躁动的作用。方法:选取2014年9月至2016年9月于我院进行气管插管七氟烷全身麻醉下腭裂修补术的患儿共120例,按随机数表法分为对照组和观察组各60例。两组患儿基础麻醉方法及手术方法相同,观察组患儿在麻醉诱导前静脉注射帕瑞昔布钠预防麻醉苏醒期躁动的发生,对照组患儿注射相同体积的生理盐水。观察记录两组患儿的术中指标,麻醉苏醒期躁动发生率,PAED,血清CRP、cTnI、S100B水平及不良反应发生情况。结果:两组患儿的麻醉时间、手术时间、拔管时间、麻醉后监测治疗室(PACU)停留时间和不良反应发生情况比较差异均无统计学意义(P均>0.05)。观察组麻醉苏醒期躁动发生率及PAED均低于对照组(P均<0.05)。术前两组患儿血清CRP、cTnI和S100B比较差异均无统计学意义(P均>0.05),术后观察组均低于对照组(P均<0.05)。结论:应用帕瑞昔布钠可安全有效地预防患儿七氟烷麻醉苏醒期躁动的发生,改善预后,可能与帕瑞昔布钠可调节CRP、cTnI和S100B水平有关。 |
| 关键词: 帕瑞昔布钠 儿童 麻醉 苏醒期躁动 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.08.006 |
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| 基金项目: |
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| Parezoxib Sodium in Prevention of Agitation during Anesthesia Recovery in Children with Cleft Palate Repair and Its Effects on Serum C-Reactive Protein, Cardiac Troponin I And S100B Protein |
| Liu Mei, Luo Zhikai, Hu Bin, Bai Zhenxi, Xiao Xia |
| (Affiliated Hospital of Yan'an University, Shaanxi Yan'an 716000, China) |
| Abstract: |
| Objective: To evaluate the effects of parezoxib sodium in prevention of agitation during anesthesia recovery in children with cleft palate repair by detecting the serum C-reactive protein (CRP), cardiac troponinI (cTnI), S100B protein levels and children’s anesthesia recovery agitation score (PAED). Methods: One hundred and twenty children undergoing cleft palate repair under general anesthesia with tracheal intubation sevoflurane in our hospital from Sept. 2014 to Sept. 2016 were extracted to be divided into control group and observation group according to the random number table method, with 60 cases in each. Methods of basic anesthesia and operation were the same in two groups; in prevention of agitation during anesthesia recovery, the observation group was given intravenous injection of parecoxib sodium before anesthesia induction, and the control group received the same volume of normal saline. The intraoperative indicators, incidence of agitation during anesthesia recovery, PAED, serum CRP, cTnI, S100B levels and incidence of adverse drug reactions of two groups were observed. Results: There was no significant difference in the anesthesia time, operation time, extubation time, post-anesthesia monitoring care unit (PACU) stay time and incidence of adverse drug reactions between two groups (P>0.05). The incidence of agitation during anesthesia recovery and PAED of observation group were lower than those of control group (P<0.05). There was no significant difference in serum CRP, cTnI and S100B between two groups before operation (P>0.05), yet the observation group was lower than the control group after treatment (P<0.05). Conclusion: The application of parecoxib sodium can safely and effectively prevent the occurrence of agitation during anesthesia recovery in children with cleft palate repair and improve the prognosis, which may be related to the regulation of CRP, cTnI and S100B levels by parecoxib sodium. |
| Key words: parecoxib sodium children anesthesia recovery period agitation |
