| 摘要: |
| [摘要] 目的：分析儿童医院住院患者常用的口服肠溶片、缓（控）释片的常用剂量，对比相关药品现有规格剂量，为儿童最适最小剂量规格确定提供参考。方法：收集2014年1月至2016年12月上海交通大学附属上海儿童医学中心住院患儿常用的口服肠溶片、缓（控）释片的全部院内处方数据，对常用剂量的使用频率进行分析。结果：儿童医院常用口服肠溶片、缓释片共5种，其中肠溶片3种，缓释片2种，无控释片。硫酸吗啡缓释片、氯化钾缓释片和奥美拉唑镁肠溶片现有剂量规格与临床需求相匹配，无需新增最小剂量规格。吲哚美辛肠溶片12.5 mg、呋喃妥因肠溶片12.5 mg或25 mg为需要新增的剂量规格。结论：现有儿童用口服肠溶片、缓（控）释片最低剂量规格与儿童医院临床实际需求不能完全匹配，建议新增适宜儿科用药的新剂型或增加相应最小剂量规格，以满足儿科用药需求。 |
| 关键词: 儿童 肠溶片 缓控释片 分剂量 最小剂量规格 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.06.011 |
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| 基金项目: |
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| Investigation on Use of Oral Sustained-Release Tablets or Enteric-Coated Tablets in Hospitalized Children from a Children’s Hospital in Shanghai |
| Xu Bulong1, Shi Fanghong2, Li Hao1, Huang Shiying1, Shen Anle1, Zhang Shunguo1, Chen Minling1 |
| (1.Shanghai Jiaotong University School of Medicine, Shanghai Children’s Medical Center, Shanghai 200127, China; 2. Shanghai Jiaotong University School of Medicine, Renji Hospital, Shanghai 200127, China) |
| Abstract: |
| [Abstract] Objective: To analyze the common dose of oral enteric coated tablets and sustained-release tablets in children’s hospital, and to compare the dose of related drug specifications, so as to provide reference for the determination of the optimum minimum dose specifications for children. Methods: Oral enteric coated tablets, sustained-release tablets prescription data were collected from Jan. 2014 to Dec. 2016 in Shanghai Children’s Medical Center. Frequency of commonly used dosage was analyzed and the most commonly used dosage rate was listed. Results: Totally 5 kinds of enteric coated tablets and sustained-release tablets were commonly used in children’s hospital including 3 kinds of enteric coated tablets, 2 kinds of sustained-release tablets and no controlled release tablets. The existing dose specifications of morphine sulfate sustained-release tablets, potassium chloride sustained-release tablets and omeprazole magnesium enteric-coated tablets matched the clinical requirements with no need to add new minimum dose specifications. Indometacin enteric-coated tablets (12.5 mg) and nitrofurantoin enteric-coated tablets (12.5 mg or 25.0 mg) were required for new dose specifications. Conclusion: The existing minimum dose specifications of oral enteric coated tablets and sustained release tablets in children’s hospital do not fully match the clinical needs. New suitable formulations of pediatric drug or a corresponding increase in the minimum dose specifications are still needed in order to meet the needs of pediatric medication. |
| Key words: children enteric coated tablets sustained-release tablets sub-dosage minimum dose specifications |
