| 本文已被：浏览 989次 下载 1049次 |
码上扫一扫！ |
| 血清降钙素原与超敏C反应蛋白预测早产儿感染严重程度的临床价值 |
| 蒋丽军1,吴明赴1,刘凤1,刘顺英1,陶建兰1,刘志峰2,张龙峰3 |
|
|
| (1. 扬州大学附属医院,江苏扬州 225001;2. 南京医科大学附属南京儿童医院,江苏南京 210093;3. 江苏大学附属医院,江苏镇江 212001) |
|
| 摘要: |
| 目的:观察血清降钙素原(PCT)和超敏C反应蛋白(hs-CRP)与早产儿细菌感染及其严重程度的关系,从而评价PCT、hs-CRP联合测定在早产儿细菌感染性疾病中的临床价值。方法:选择扬州大学附属医院新生儿重症监护病房(NICU)收治的细菌感染性疾病早产儿60例,按临床诊断标准分为重症感染组和局部感染组。所有患儿分别于入院时和治疗7 d后进行PCT、hs-CRP水平检测,并随机选取30例非感染早产儿作为对照组,统计分析PCT、hs-CRP水平与早产儿感染类型、感染严重程度、治疗效果关系。结果:治疗前,感染组早产儿PCT、hs-CRP水平均高于非感染组,重症感染组均明显高于局部感染组、非感染组,差异有统计学意义(P<0.05或P<0.01)。PCT、hs-CRP水平重症感染组>局部感染组>非感染组。治疗7 d后,感染组早产儿PCT、hs-CRP水平均较治疗前明显降低(P<0.01)。结论:联合检测血清PCT、hs-CRP 对诊断早产儿感染、病情严重程度具有重要价值,是早产儿感染性疾病诊断、病情评估和治疗效果评价的可靠依据。 |
| 关键词: 降钙素原 超敏C反应蛋白 早产儿 感染 |
| DOI：doi:10-13407/j.cnki.jpp.1672-108X.2018.09.002 |
|
| 基金项目: |
|
| Detection of Procalcitonin and C-Reaction Protein in Premature Neonates with Infectious Diseases |
| Jiang Lijun1, Wu Mingfu1, Liu Feng1, Liu Shunying1, Tao Jianlan1, Liu Zhifeng2, Zhang Longfeng3 |
| (1. Hospital Affiliated to Yangzhou University, Jiangsu Yangzhou 225001, China; 2. Nanjing Children's Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210093, China; 3. Hospital Affiliated to Jiangsu University, Jiangsu Zhenjiang 212001, China) |
| Abstract: |
| Objective: To observe the relationship between procalcitonin (PCT), hypersensitive C-reaction protein (hs-CRP) and bacterial infection and its severity in premature neonates, so as to evaluate the clinical value of combined detection of PCT and hs-CRP in premature neonates with infectious diseases. Methods: Sixty premature neonates with infectious diseases admitted into neonatal intensive care unit (NICU) in Hospital Affiliated to Yangzhou University were extracted to be divided into severe infectious group and local infectious group according to the clinical diagnostic criteria. All patients were tested for PCT and hs-CRP levels at admission and 7 days after treatment; and 30 non-infectious premature neonates were selected randomly as the control group. Statistical analysis was conducted on the relationship between PCT, hs-CRP and the types, severity of infection, treatment effects, respectively. Results: Before treatment, the serum PCT and hs-CRP levels of infectious group were higher than those of non-infectious group, and the (P<0.05 or P<0.01). The serum PCT and hs-CRP levels of three groups were respectively: severe infectious group > local infectious group > non-infectious group. After treatment of 7 d, the serum PCT and hs-CRP levels of infectious group decreased significantly compared with before treatment (P<0.01). Conclusion: Combined detection of serum PCT and hs-CRP levels has important value on the diagnosis of premature neonates’ infection and the severity in bacterial infection of premature neonates. It is a reliable basis for the diagnosis, disease evaluation and therapeutic evaluation of infectious diseases in premature infants. |
| Key words: procalcitonin hypersensitive C-reaction protein premature neonate infection |
