| 摘要: |
| 目的:研究米力农联合去甲肾上腺素治疗婴幼儿难治性休克的临床疗效。方法:选取我院2015年4月至2017年4月收治的120例难治性休克婴幼儿,其中男63例,女57例,年龄1~3 (1.7±0.3)岁,将所有研究对象随机分为对照组和试验组各60例。对照组给予去甲肾上腺素,试验组给予米力农联合去甲肾上腺素,观察两组患儿治疗总有效率以及治疗前后心率、血压以及心脏指数变化。结果:米力农联合去甲肾上腺素的治疗有效率为93.33%,显著高于单用去甲肾上腺组的有效率(71.67%),差异有统计学意义(χ2=9.755, P<0.05)。治疗前两组患儿的心率、血压以及心脏指数比较差异无统计学意义(P>0.05);治疗后两组患儿心率、血压以及心脏指数与治疗前比较差异有统计学意义(P<0.05),且治疗后试验组患儿的心率、血压以及心脏指数改善程度显著优于单用去甲肾上腺组,差异有统计学意义(P<0.01)。结论:米力农联合去甲肾上腺素能有效提高难治性休克的治疗效果,安全可靠,值得临床推广应用。 |
| 关键词: 米力农 去甲肾上腺素 婴幼儿 难治性休克 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.07.007 |
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| 基金项目: |
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| Melion Combined with Norepinephrine in the Treatment of Refractory Shock in Infants |
| Yu Xinqiao, Zhang Yongfang, Zhao Jihua, Pu Yuanlin |
| (Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Enshi 445000, China) |
| Abstract: |
| Objective: To investigate the clinical efficacy of melion combined with norepinephrine in the treatment of refractory shock in infants. Methods: One hundred and twenty infants with refractory shock admitted into our hospital from Apr. 2015 to Apr. 2017 were extracted as the subjects, of which 63 cases were males and 57 cases were females, with age of 1-3 (1.7±0.3) years. And all subjects were randomly divided into control group and experimental group, with 60 cases in each. The control group was given norepinephrine, while the experimental group received melion combined with norepinephrine. The total effective rate and changes of heart rate, blood pressure and heart indexes of two groups were observed before and after treatment. Results: The total effective rate of experimental group was 93.33%, significantly higher than that of control group 71.67%, with statistically significant difference (χ2=9.755, P<0.05). There was no statistically significant difference between two groups in heart rate, blood pressure and heart indexes before treatment (P>0.05). Yet the differences were statistically significant between two groups in heart rate, blood pressure and heart indexes after treatment (P<0.05), and the improvements of heart rate, blood pressure and heart indexes in experimental group were significantly better than those in control group, with statistically significant difference (P<0.01). Conclusion: Melion combined with norepinephrine can effectively improve the therapeutic effects of refractory shock, with safe and reliable efficacy. It is worthy of clinical application and promotion. |
| Key words: milrinone norepinephrine infants refractory shock |
