| 摘要: |
| 目的:探讨健脾利胆合剂联合熊去氧胆酸治疗婴儿胆汁淤积症的临床效果。 方法:选择2015 年6 月至2017 年6 月我院收治的 72 例胆汁淤积症患儿,随机分为对照组和观察组各 36 例。 对照组给予熊去氧胆酸,观察组给予熊去氧胆酸和健脾利胆合剂,比较两组患儿临床治疗效果、血清学生化指标水平和不良反应发生情况。 结果:治疗后对照组和观察组的总胆红素(TBIL)、直接胆红素(DBIL)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和 酌鄄谷氨酰胺转移酶(GGT)水平较治疗前显著降低(P<0.05),观察组 TBIL、DBIL、ALT、AST 和 GGT 水平显著低于对照组(P<0.05)。 观察组患儿治疗总有效率97.22%,显著高于对照组的 75.00%(P<0.05)。 两组患儿不良反应发生率比较差异无统计学意义(P>0.05)。 结论:健脾利胆合剂联合熊去氧胆酸能够明显提高婴儿胆汁淤积症的治疗效果,值得临床推广应用。 |
| 关键词: 健脾利胆合剂 熊去氧胆酸 胆汁淤积症 婴儿 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2018.05.009 |
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| 基金项目: |
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| Jianpi Lidan Mixture Combined with Ursodeoxycholic Acid for the Treatment of Infants with Cholestasis |
| Zhang Shichao, Wang Shasha, Li Jingfeng, Ding Na, Ren Jianhong |
| (Shiyan Taihe Hospital Affiliated to Hubei University of Medical, Hubei Shiyan 442000, China) |
| Abstract: |
| Objective: To explore the clinical effect of Jianpi Lidan mixture combined with ursodeoxycholic acid for the treatment of infants with cholestasis. Methods: A total of 72 cases of infants with cholestasis were admitted into our hospital from June 2015 to June
2017. The children were randomly divided into two groups of 36 cases in each. The control group was given ursodeoxycholic acid, and
the observation group was given the Jianpi Lidan mixture combined with ursodeoxycholic acid. The therapeutic effect, serum biochemical indexes and the drug adverse reactions of the two groups were compared. Results: TBIL, DBIL, ALT, AST and GGT levels in the two groups were significantly reduced compared with those before treatment (P<0.05). The serum biochemical indexes of the observation group were significantly lower than the control group (P<0.05). The total effective rate of children in the observation group (97.22%) was significantly higher than that in the control group 75.00%, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of drug adverse reactions between the two groups (P>0.05). Conclusion: The treatment effect of Jianpi Lidan mixture combined with ursodeoxycholic acid for infants with cholestasis is significantly improved.There are broad prospects for clinical application. |
| Key words: Jianpi Lidan mixture ursodeoxycholic acid cholestasis infants |
