| 摘要: |
| [摘要]目的：探讨影响新生儿坏死性小肠结肠炎（NEC）患儿疾病严重程度的危险因素。方法：采用回顾性研究，选择2010年1月至2016年5月在我院新生儿中心住院的新生儿，符合NEC诊断且Bell分期≥Ⅱ期。采用单因素分析和二元Logistic回归分析，讨论NEC严重程度相关的危险因素。结果：本研究共纳入197例新生儿，其中NEC Ⅱ期组121例，Ⅲ期组76例；单因素分析结果表明：胎龄、发病日龄、溶血症、败血症、CRP>8 mg/L、休克、血小板减少症、确诊前胃肠减压的时间两组比较差异均有统计学意义（P<0.05）；将单因素分析提示差异有统计学意义的变量，进一步进行二元Logistic回归分析，得到发病日龄（OR：0.958，95% CI：0.927，0.991，P<0.05）、胎龄（OR：0.872，95% CI：0.784，0.971，P<0.05）和确诊前胃肠减压的时间（OR：1.377，95%CI：1.054-1.801，P<0.05）为影响NEC严重程度的危险因素。结论：发病日龄及胎龄越小、确诊前胃肠减压的时间越长的患儿越容易发展至NEC Ⅲ期。因此应高度重视胎龄小的NEC患儿，缩短胃肠减压的时间，以降低NEC患儿病情的严重程度。 |
| 关键词: 新生儿 坏死性小肠结肠炎 危险因素 胃肠减压 发病日龄 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2019.02.005 |
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| 基金项目: |
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| Risk Factors for the Severity of Neonatal Necrotizing Enterocolitis |
| Du Yue, Zhong Qin, Feng Hui, Lu Qi |
| (Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorder; China International Science and Technology Cooperation Base of Child Development and Critical Disorders; Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
| Abstract: |
| [Abstract] Objective: To probe into the risk factors that affecting the severity of NEC (neonatal necrotizing enterocolitis). Methods: Retrospective method was adopted, neonates admitted into the neonatal center of our hospital from Jan. 2010 to May 2016 were selected, and all patients were eligible for NEC diagnosis and Bell stage ≥ Ⅱ. Univariate analysis and binary Logistic regression analysis were adopted to discuss the risk factors associated with NEC severity. Results: A total of 197 neonates were included in this study, including 121 cases in the NEC Ⅱ group and 76 cases in the Ⅲ group. Univariate analysis showed that differences of gestational age, onset age, hemolysis, sepsis, CRP>8 mg/L, shock, thrombocytopenia, and time of gastrointestinal decompression before diagnosis were statistically significant between two groups (P<0.05). Univariate analysis was used to indicate the statistically significant differences, and further binary Logistic regression analysis was performed to obtain the onset age (OR: 0.958, 95% CI: 0.927, 0.991, P<0.05) and gestational age (OR: 0.872, 95% CI: 0.784, 0.971, P<0.05) and time of gastrointestinal decompression before diagnosis (OR: 1.377, 95% CI: 1.054-1.801, P<0.05) were the risk factors for the severity of NEC. Conclusion: The younger the onset age and the gestational age and the longer the time of gastrointestinal decompression before diagnosis, the easier it is to develop to NEC Ⅲ. Therefore, great attention should be paid to the smaller age of NEC children, to shorten the time of gastrointestinal decompression, so as to reduce the severity of NEC children. |
| Key words: neonates necrotizing enterocolitis risk factors gastrointestinal decompression onset age |
