| 摘要: |
| 目的:比较双氯芬酸钠栓剂和曲马多针剂用于儿童骨折术后镇痛的效果。方法:将150例骨折手术的患儿随机分为A、B两组各75例,A组术后立即使用双氯芬酸钠栓剂塞肛,B组术后静脉注射曲马多,分别记录术后1 h、2 h、4 h、8 h、12 h、24 h东安大略儿童医院疼痛评分(CHEOPS)及术后不良反应发生情况。结果:A组和B组术后疼痛镇痛效果良好,在术后1 h、2 h、4 h、8 h、12 h、24 h CHEOPS比较差异无统计学意义(P>0.05)。A组不良反应发生率为10.67%(8/75),B组不良反应发生率为34.67%(26/75),两组比较差异有统计学意义(χ2=12.323，P<0.01)。两组患儿均未发现药物过敏、呼吸抑制等严重不良反应。结论:双氯芬酸钠栓剂用于骨折术后镇痛的效果与曲马多针剂无差异,但不良反应更少,用法更简单。 |
| 关键词: 双氯芬酸钠栓剂 曲马多针剂 术后镇痛 儿童 |
| DOI：doi:10.13407/j.cnki.jpp.1672.108X-2018.07.004 |
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| 基金项目: |
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| Comparison of Postoperative Analgesia Effects between Diclofenac Sodium Suppository and Tramadol Injection in Children with Fracture |
| Zheng Minzhi, Xue Bin, Lin Kana |
| (Shanghai Children's Medical Center Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China) |
| Abstract: |
| Objective: To compare the postoperative analgesia effects between diclofenac sodium suppository and tramadol injection in children with fracture. Methods: One hundred and fifty children undergoing fracture surgery were randomly divided into group A and group B. Group A was treated with diclofenac sodium suppository and group B received intravenous tramadol injection after fracture surgery. The CHEOPS pain scores and postoperative adverse drug reactions were recorded at 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after surgery. Results: The postoperative analgesia effects were good in both groups after operation, and there was no statistically significant difference in CHEOPS pain scores at 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after surgery (P>0.05).The incidence of adverse drug reactions in group A was 10.67%(8/75), and in group B was 34.67%(26/75), with statistically significant difference(χ2=12.323，P<0.01). Other severe adverse reactions such as drug allergy and respiratory depression were not found in both groups. Conclusion: The postoperative analgesia effects of diclofenac sodium suppository for postoperative analgesia has no difference compared with tramadol injection, but with fewer adverse drug reactions and easier usage. |
| Key words: diclofenac sodium suppository tramadol injection postoperative analgesia children |
