| 摘要: |
| 目的:探讨不同剂量丙泊酚在儿童全身麻醉中的临床效果。方法:86例患儿按随机数表法分为对照组和研究组各43例。对照组给予大剂量丙泊酚麻醉,研究组给予小剂量丙泊酚麻醉,比较两组患儿复苏期质量、血流动力学、应激反应、并发症发生情况。结果:研究组苏醒时间、镇静-躁动评分(SAS)及麻醉恢复室(PACU)停留时间均少于对照组,差异有统计学意义(P>0.05),两组拔管时间比较差异无统计学意义(P>0.05)。两组患儿麻醉诱导前、插管前1min、插管后1min、切皮前1min、切皮后1min、手术探查时及手术结束时各时间点血流动力学值差异均有统计学意义(P<0.05);两组患儿相同时间点血流动力学值差异均无统计学意义(P>0.05)。两组患儿各时间点心率及平均动脉压(MAP)变化差异均有统计学意义(P<0.05);其中研究组患儿心率下降幅度较小,MAP波动较平稳,对照组患儿心率下降幅度较大,MAP波动较大(P<0.05)。两组患儿均有低血压、心动过速或过缓等并发症发生,组间并发症发生率比较差异无统计学意义(P>0.05)。结论:小剂量丙泊酚对儿童全身麻醉中的血流动力学的影响较小,能够提高患儿复苏期质量,增加麻醉安全性及有效性。 |
| 关键词: 全身麻醉 不同剂量丙泊酚 血流动力学 复苏效果 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2018.12.004 |
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| 基金项目: |
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| Effects of Different Doses of Propofol on Hemodynamics and Resuscitation in Children during General Anesthesia |
| Song Wei, Tian Youfang, Hu Bin, Xu Zhifa |
| (Fujian Zhangzhou Zhengxing Hospital, Fujian Zhangzhou 363000, China) |
| Abstract: |
| Objective: To explore the clinical effects of different doses of propofol on children during general anesthesia. Methods: Eighty-six children were divided into control group and research group via the random number table, with 43 cases in each group. The control group was given a high-dose of propofol anaesthesia, while the research group received a low-dose of propofol anesthesia. The quality of resuscitation, hemodynamics, stress response and complications were compared between two groups. Results: The recovery time, sedation-incitement score (SAS) and staying time of the postanesthesia care unit (PACU) in the research group were all lower than those in the control group, and the differences were statistically significant (P>0.05), and the decannulation time in two groups had no difference (P>0.05). Differences of hemodynamics between two groups before induction of anesthesia, 1 min before intubation, 1 min after intubation, 1 min before incision, 1 min after incision, at the time of surgical exploration and at the end of surgery were statistically significant (P<0.05), and there were no significant difference in hemodynamics between two groups at the same time point (P>0.05). There were significant differences in heart rate and mean arterial pressure (MAP) between two groups (P<0.05), among which, the heart rate of the research group was smaller, the MAP fluctuation of research group was stable, yet the heart rate of the control group decreased significantly with large fluctuation of MAP (P<0.05). There was no significant difference in the incidence of complications between two groups (P>0.05). Conclusion: Low-dose propofol has less effects on hemodynamics in children during general anaesthesia, which can improve the quality of children’s resuscitation, and increase the safety and effectiveness of anesthesia. |
| Key words: general anesthesia propofol hemodynamics resuscitation effects |
