| 摘要: |
| 目的：比较枸橼酸咖啡因与氨茶碱对早产儿呼吸暂停的治疗效果及对血气指标的影响。方法：选取2016年3月至2017年12月我院收治的原发性呼吸暂停早产儿96例，随机分为枸橼酸咖啡因组和氨茶碱组各48例，分别给予相应药物治疗，比较两组患儿的临床疗效、发作次数、呼吸暂停消失时间、住院时间、血气指标及并发症的发生情况。结果：枸橼酸咖啡因组总有效率为93.75%，高于氨茶碱组的70.83%（P<0.05）。治疗后，枸橼酸咖啡因组患儿呼吸暂停发作次数少于氨茶碱组；呼吸暂停消失时间、氧疗时间及住院时间均短于氨茶碱组（P均<0.01）；两组患儿的PaO2、PaO2/FiO2均升高，且枸橼酸咖啡因组高于氨茶碱组（P均<0.05）；两组患儿的PaCO2均降低，且枸橼酸咖啡因组低于氨茶碱组（P均<0.05）。枸橼酸咖啡因组患儿的并发症发生率低于氨茶碱组（P<0.05）。结论：枸橼酸咖啡因治疗早产儿呼吸暂停的临床效果显著，能有效改善血气指标、减少不良反应，比氨茶碱更具优势。 |
| 关键词: 枸橼酸咖啡因 氨茶碱 早产儿 呼吸暂停 血气指标 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2019.01.010 |
|
| 基金项目: |
|
| Clinical Effect of Citron and Aminophylline in the Treatment of Prematureinfants with Apnea and Its Effect on Blood Gas Index |
| Chen Mingshuang, Yang Jun |
| (Fengjie County People’s Hospital of Chongqing, Chongqing 404600, China) |
| Abstract: |
| Objective: To investigate the effect of citron and aminophylline in the treatment of premature infants with apnea and the effect on blood gas index. Methods: Select 96 cases of primary apnea preterm infants who were admitted to our hospital from March 2016 to December 2017, and randomly divided them into observation group and control group. The observation group and control group were treated with caffeine citrate and aminophylline, respectively. The clinical effect, the number of episodes, the time of apnea disappeared, the time of hospitalization, the blood gas index and the incidence of complications in the two groups were compared. Results: A total of 45 patients in the observation group were effective, and the total effective rate was 93.75%. A total of 34 patients in the control group were effective, and the total effective rate was 70.83%. The total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the number of attacks in the observation group was lower than that in the control group (P<0.05). The time of apnea disappeared, oxygen therapy time and the time of hospitalization in the observation group were shorter than those in the control group (P<0.05). Before treatment, there was no statistical difference in PaO2, PaCO2 and PaO2/FiO2 between the two groups (P>0.05). After treatment, PaO2, PaO2/FiO2 in both the observation group and the control group increased, and the observation group had higher PaO2, PaO2/FiO2 than that of the control group, all differences were significant (P<0.05). After treatment, the PaCO2 of the two groups decreased, but the PaCO2 of the observation group was lower than that of the control group, the difference was statistically significant (P<0.05). The incidence of complications in the observation group was lower than that in the control group, all differences were significant (P<0.05). Conclusion: Caffeine citrate has a significant clinical effect in the treatment of apnea in premature infants. It can improve blood gas indicators and reduce adverse reactions more effectively. |
| Key words: caffeine citrate aminophylline prematurity apnea blood gas index |
