| 摘要: |
| 目的：评价哮喘儿童呼吸道支原体检出率对临床预后和生存质量（QOL）的影响。方法：选择2014年1月至2016年12月在我院就诊的支气管哮喘患儿35例，随访12个月，每2个月一次随访进行哮喘控制问卷（ACQ）、小儿哮喘照护者生命质量问卷（PACQLQ）、药物指数和哮喘严重指数（ACQ与药物指数之和）评价，同时取咽部分泌物进行肺炎支原体（MP）培养，比较MP阳性率与ACQ、PACQLQ、药物指数和哮喘严重指数的相关性。结果：平均每人随访5.32（4.00~7.50）次，其中21例完成6次随访，11例完成3~6次随访，1例完成2次随访；共有20例患儿MP培养阳性，其中阳性率最高的月份为5月和7月；入组后患儿哮喘严重指数和PACQLQ均无明显变化，但Pearson相关分析表明不同时点两指标均存在负相关（P<0.05）；MP阳性访视和阴性访视之间药物指数、ACQ、PACQLQ、哮喘严重指数比较差异均无统计学意义（P>0.05）。结论：支气管哮喘患儿MP阳性率与临床症状、QOL无相关性。 |
| 关键词: 肺炎支原体 哮喘 临床症状 生存质量 |
| DOI： |
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| 基金项目: |
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| Detection Rate of Respiratory Mycoplasma in Children with Asthma and Its Effects on Clinical Prognosis |
| Wang Yanni, Han Peng |
| (Baoji Maternal and Child Health Hospital, Baoji Children’s Hospital, Shaanxi Baoji 721000, China) |
| Abstract: |
| Objective: To evaluate the effects of detection rate of respiratory Mycoplasma in children with asthma on clinical prognosis and quality of life (QOL). Methods: Totally 35 children with asthma admitted into our hospital from Jan. 2014 to Dec. 2016 were followed up for 12 months. Evaluation of asthma control questionnaire (ACQ), Pediatric Asthma Career Quality of Life Questionnaire (PACQLQ), drug index and asthma severity index (sum of ACQ and drug index) was conducted every 2 months. In the meantime, the pharyngeal secretions were taken for Mycoplasma pneumoniae (MP) culture, and the correlation between MP positive rate and ACQ, PACQLQ, drug index and asthma severity index was compared. Results: The average follow-up was 5.32 (from 4.00 to 7.50) times per person, and 21 cases completed 6 follow-ups, 11 cases completed 3 to 6 follow-ups, and 1 case completed 2 follow-ups. A total of 20 children were positive for MP culture, and the highest positive rate was May and July. After admission, there were no significant changes in asthma severity index and PACQLQ, but Pearson correlation analysis showed that there was negative correlation between the two indexes at different time points (P<0.05). There was no significant difference in drug index, ACQ, PACQLQ and asthma severity index between MP positive and negative visits (P>0.05). Conclusion: The positive rate of MP in children with bronchial asthma is not associate with clinical symptoms and QOL. |
| Key words: Mycoplasma pneumoniae asthma clinical symptoms quality of life |
