| 摘要: |
| 局灶性皮质发育不良(focal cortical dysplasia,FCD)是皮质发育畸形(malformation of cortical development,MCD)的一个特殊亚型,是大脑发育过程中神经元迁移、增殖和分化过程破坏的结果,导致区域皮质分层、神经元成熟和分化异常。FCD通常表现为药物难治性癫痫,是癫痫手术中最常见的皮质畸形类型。2011 年国际抗癫痫联盟(ILAE)在Palmini 等分类基础上将FCD 分为三型———FCD玉型是指单纯皮质结构异常,包括皮质径向分层异常(FCD玉a)、切向分层异常(FCD玉b)及切向和径向均异常(FCD玉c);FCD域a 指皮质发育不良伴异形神经元,FCD域b 指皮质发育不良伴异形神经元和气球样细胞;FCD 芋则合并其他脑部病变,如海马硬化(FCD芋a)、神经胶质瘤、血管畸形及其他早年获得性脑损伤。本文旨在对FCD 相关癫痫的致痫机制、临床特征及治疗进展进行综述,以期为临床提供参考。 |
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| DOI：10.13407/j.cnki.jpp.1672-108X.2019.11.019 |
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| 基金项目: |
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| Progress of Epilepsy Associated with Focal Cortical Dysplasia |
| Ran Longfeng, Cao Jie |
| (Children,s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China) |
| Abstract: |
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