| 摘要: |
| [摘要]目的：分析儿童细菌感染性腹泻的临床特点、病原菌分布及耐药性，指导临床诊治。方法：回顾性分析本院2017年1-12月诊治的296例细菌感染性腹泻患儿的临床资料。结果：296例患儿中，男171例，女125例，男女比为1.37:1；5岁以下儿童239例，占80.74%；发病时间集中于5~9月（79.39%）；临床表现为腹泻、发热、腹痛、黏液糊便，部分表现为血便，大便次数以5~10次居多；沙门菌166例（56.08%），大肠埃希菌73例（24.66%），类志贺邻单胞菌41例(13.85%)，副溶血弧菌15例（5.07%），志贺菌1例（0.34%）。所有细菌对亚胺培南、哌拉西林他唑巴坦均敏感（敏感率100%）；沙门菌和致泻性大肠埃希菌对头孢他啶的敏感率分别为75.00%、93.55%，对头孢曲松的敏感率分别为67.31%、80.65%，对三代头孢菌素药物有不同程度耐药；副溶血弧菌药物敏感性较高。结论：儿童细菌感染性腹泻发病率高，传播快，耐药率高。临床应尽早完善病原学检查，合理选用抗生素。 |
| 关键词: 细菌感染性腹泻 沙门菌 致泻性大肠埃希菌 耐药性 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2020.05.008 |
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| 基金项目: |
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| Clinical Characteristics and Pathogens of Children with Bacterial Diarrhea |
| Wang Pingping, Liu Di, Jin Xuefeng |
| (Hangzhou Children’s Hospital, Zhejiang Hangzhou 310014, China) |
| Abstract: |
| [Abstract] Objective: To analyze the clinical characteristics, pathogenic bacteria and drug resistance of children with bacterial diarrhea, so as to guide clinical diagnosis and treatment. Methods: Retrospective analysis was conducted on clinical data of 296 children with bacterial diarrhea admitted into our hospital from Jan. to Dec. 2017. Results: Among the 296 children, 171 cases were male and 125 cases were female, the ratio of male to female was 1.37∶1. There were 239 children under 5 years old, accounting for 80.74%. The onset time was concentrated in 5 to 9 months (79.39%). The clinical manifestations were diarrhea, fever, abdominal pain, mucous stool, some of which were bloody stool, and the number of stools was 5 to 10 times. There were 166 cases (56.08%) of Salmonella, 73 cases (24.66%) of Escherichia coli, 41 cases (13.85%) of Orthomonas shigella, 15 cases (5.07%) of Vibrio parahaernolyticus, and 1 case (0.34%) of Shigella. All bacteria were sensitive to imipenem and piperacillin tazobactam (with sensitivity rate of 100%). The sensitivity rates of Salmonella and diarrhogenic E. coli to ceftazidime and cefatriaxone were 75.00%, 93.55% and 67.31%, 80.65%, respectively, with different degrees of resistance to the three generation cephalosporins. V. parahaemolyticus was highly sensitive to drugs. Conclusion: Children with bacterial diarrhea have higher incidence, faster transmission and higher drug resistance. Clinical examination should be completed as soon as possible, and antibiotics should be chosen rationally. |
| Key words: bacterial diarrhea Salmonella diarrhoea Escherichia coli drug resistance |
