| 摘要: |
| [摘要]目的：比较盐酸哌甲酯控释片（专注达）治疗注意缺陷为主型、冲动-多动为主型以及混合型注意缺陷多动障碍（ADHD）患儿的疗效。方法：选取2017年7月至2018年8月我院诊治的ADHD患儿100例，根据DSM-Ⅳ中ADHD诊断标准分为三组，分别为ADHD-I组（注意缺陷为主型）33例、ADHD-HI组（冲动-多动为主型）33例和ADHD-C组（混合型）34例。三组患儿均采用盐酸哌甲酯控释片治疗，18 mg/d，疗程为6周。采用SNAP-Ⅳ父母评定量表及Conners父母症状评价量表评价疗效，观察并比较三组患儿的治疗效果及不良反应情况。结果：治疗后三组患儿在SNAP-Ⅳ和Conners量表中各指标均得到显著改善，且ADHD-HI组患儿改善幅度大于ADHD-I组和ADHD-C组（P均<0.05），而ADHD-I组和ADHD-C组改善幅度比较差异无统计学意义（P均>0.05）。ADHD-HI组患儿总有效率84.85%（28/33），较ADHD-I组的66.67%（22/33）和ADHD-C组的73.53%（25/34）高（P均<0.05）。三组不良反应发生率的比较差异无统计学意义（P>0.05）。结论：盐酸哌甲酯控释片治疗ADHD患儿有显著疗效，但不同亚型间的疗效存在差异。 |
| 关键词: 盐酸哌甲酯控释片 注意缺陷多动障碍 亚型 SNAP-Ⅳ父母评定量表 Conners父母症状评价量表 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2019.09.004 |
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| 基金项目: |
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| Comparison of Efficacy of Methylphenidate Hydrochloride Prolonged-Release Tablets in the Treatment of Different Subtypes of Attention Deficit Hyperactivity Disorder |
| Ye Bei, Fang Shuanfeng, Zhang Yun |
| (Children’s Hospital Affiliated to Zhengzhou University, Henan Zhengzhou 450000, China) |
| Abstract: |
| [Abstract] Objective: To compare the efficacy of methylphenidate hydrochloride prolonged-release tablets in the treatment of children with attention deficit-based, impulsive-hyperactive-based and mixed attention deficit hyperactivity disorder (ADHD). Methods: A total of 100 children with ADHD admitted into our hospital from Jul. 2017 to Aug. 2018 were enrolled. According to the American Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-Ⅳ), all children were respectively divided into 33 cases of ADHD-I group (attention deficit-based), 33 cases of ADHD-HI group (impulsive-hyperactive-based) and 34 cases of ADHD-C group (mixed). Three groups were treated with methylphenidate hydrochloride prolonged-release tablets, 18 mg/d, for 6 weeks. The SNAP-Ⅳ parental rating scale and Conners parental symptom assessment scale were used to evaluate the therapeutic effects of three groups of children. The clinical effects and adverse drug reactions were observed and recorded. Results: After treatment, the SNAP-Ⅳ and Conners parental symptom assessment scale were significantly improved in three groups, and the improvement in the ADHD-HI group was greater than that in the ADHD-I group and the ADHD-C group (P<0.05), while there was no significant difference in the improvement between the ADHD-I group and the ADHD-C group (P>0.05). The total effective rate of ADHD-HI group was 84.85% (28/33), higher than that of ADHD-I group 66.67% (22/33) and ADHD-C group 73.53% (25/34), the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse drug reactions among three groups (P>0.05). Conclusion: The efficacy of methylphenidate hydrochloride prolonged-release tablets in the treatment of children with ADHD is significant, yet there are differences in efficacy between different subtypes. |
| Key words: methylphenidate hydrochloride prolonged-release tablets attention deficit hyperactivity disorder subtypes SNAP-Ⅳ parental rating scale Conners parental symptom assessment scale |
