| 摘要: |
| 目的：考察两种注射用水溶性维生素对新生儿肠外营养液稳定性的影响。方法：采用同样的调配方法，以注射用水溶性维生素的临床常用量1.5 mL和临床最大使用量3 mL为依据，将添加（实验组）和不添加（对照组）对羟基苯甲酸甲酯的两种注射用水溶性维生素分别调配成新生儿肠外营养液，将其置于避光室温（25 ℃）下存放，于调配后的0 h、12 h、24 h考察外观变化、pH值、乳粒粒径大小、粒度分布、不溶性微粒以及细菌生长情况等。结果：按临床常用量或临床最大使用量配制的实验组和对照组样品的pH值、乳粒粒径大小、不溶性微粒数、细菌生长情况差异均无统计学意义（P均>0.05）。两组PDI值比较差异有统计学意义（P<0.05），但各样品的PDI值均<0.2，乳滴的单分散性良好。结论：两种注射用水溶性维生素（添加和不添加对羟基苯甲酸甲酯）调配的新生儿肠外营养液的稳定性均较好，临床可以根据实际情况选用。 |
| 关键词: 注射用水溶性维生素 新生儿肠外营养液 稳定性 |
| DOI： |
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| 基金项目: |
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| Effects of Two Kinds of Water-Soluble Vitamins for Injection on the Stability of Neonatal Parenteral Nutrition Solution |
| Wang Jing1, Zhang Lifeng1, Zhao Ruiling2 |
| (1. Shanxi Medical University, Shanxi Taiyuan 030001, China; 2. Children’s Hospital of Shanxi, Shanxi Taiyuan 030013, China) |
| Abstract: |
| Objective: To investigate the effects of two kinds of water-soluble vitamins for injection on the stability of neonatal parenteral nutrition solution. Methods: Using the same blending method, based on the commonly clinical use amount of water-soluble vitamins for injection of 1.5 mL and the maximum clinical use amount of 3 mL, the two kinds of water-soluble vitamins for injection with addition (experimental group) and without addition (control group) of methyl parahydroxybenzoats were separately formulated into neonatal parenteral nutrition solution. The solution was stored at the dark room (temperature 25 ℃) and tested for appearance changes, pH value, emulsion grains particle size, particle size distribution, insoluble particles and bacterial growth at 0 h, 12 h and 24 h after preparation. Results: There was no statistically significant difference in pH value, emulsion grains particle size, number of insoluble particles and bacterial growth in the samples of the experimental group and the control group prepared according to the commonly clinical use amount or the maximum clinical use amount (P>0.05). The PDI value of the samples in two groups were statistically different (P<0.05), yet the PDI values of all samples were <0.2, which indicated the good monodispersity of emulsion droplet. Conclusion: The stability of neonatal parenteral nutrition solution prepared by two kinds of water-soluble vitamins for injection (with or without addition of methyl parahydroxybenzoats) is better, which can be used in the clinic according to the actual situation. |
| Key words: water-soluble vitamins for injection neonatal parenteral nutrition stability |
