| 摘要: |
| 目的:探讨干扰素α1b注射液不同给药方式对小儿传染性单核细胞增多症的疗效。方法:选择120例确诊为传染性单核细胞增多症的患儿作为研究对象,按随机数字表法分为观察组和对照组各60例,观察组给予2 µg/kg干扰素α1b注射液加入4 mL生理盐水中雾化吸入15 min,每天2次,对照组给予1 µg/kg干扰素α1b注射液肌肉注射,每天1次,两组患儿同时给予2 mg/kg更昔洛韦静脉滴注,每天2次,所有药物疗程均为5 d,比较两组患儿的临床疗效及不良反应发生情况。结果:观察组退热时间和咽峡炎好转时间均短于对照组,差异有统计学意义(P<0.05);两组患儿异型淋巴细胞消失时间、肝脾及淋巴结恢复正常时间、EB病毒转阴率和免疫功能恢复情况差异无统计学意义(P>0.05);观察组总有效率高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:干扰素α1b注射液雾化吸入治疗小儿传染性单核细胞增多症能更快改善症状,且用药安全性高,值得临床推广。 |
| 关键词: 干扰素α1b 注射液 传染性单核细胞增多症 雾化吸入 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2019.08.004 |
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| 基金项目:重庆市黔江区科技计划项目,黔科计2017030。 |
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| Comparison of Different Administration Methods of Interferon α1b in Children with Infectious Mononucleosis |
| Deng Shengyong, Pu Xiangyang |
| (Qianjiang Central Hospital of Chongqing, Chongqing 409000, China) |
| Abstract: |
| Objective: To probe into the efficacy of different administration methods of interferon α1b in children with infectious mononucleosis. Methods: Totally 120 children diagnosed with infectious mononucleosis were extracted to be divided into the observation group and the control group via the random number table, with 60 cases in each group. The observation group was given 2 µg/kg interferon α1b injection and added into 4 mL of normal saline for aerosol inhalation for 15 min, twice a day. The control group received intramuscular injection of 1 µg/kg interferon α1b injection, once a day. And 2 mg/kg ganciclovir were given intravenously twice a day for two groups. All treatment courses were 5 d. The clinical efficacy and adverse drug reactions of two groups were compared. Results: The relief time of fever and the improvement time of pharyngitis in the observation group were significantly shorter than those in the control group, with statistically significant differences (P<0.05). There was no significant difference in the disappearance time of atypical lymphocytes, the recovery time of liver and spleen and lymph nodes, the rate of EB virus negative conversion and the recovery of immune function between two groups (P>0.05). The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The incidence of adverse drug reactions in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion: Aerosol inhalation of interferon α1b injection in the treatment of children with infectious mononucleosis can improve symptoms more quickly and has better medication safety, which is worthy of clinical promotion. |
| Key words: interferon α1b injection infectious mononucleosis aerosol inhalation |
