| 摘要: |
| 目的：分析我院极低/超低出生体质量儿早发败血症（EOS）及晚发败血症（LOS）的病原分布，探讨其危险因素。方法：收集我院2012-2017年收治的极低/超低出生体质量儿临床资料，分为EOS组、LOS组及未发生败血症的对照组，回顾性分析败血症发病率、病原谱及危险因素。结果：共纳入777例极低/超低出生体质量儿，其中EOS组 106例（13.6%），LOS组 245例（31.5%）。共培养出9株EOS病原菌，大肠埃希菌占44.4%；130株LOS病原菌，肺炎克雷伯菌占39.2%。EOS患儿胎膜早破、产后心肺复苏、生后第1天机械通气概率高于对照组（P均<0.05）。LOS患儿机械通气概率高于对照组，剖宫产概率低于对照组（P均<0.05）。结论：胎膜早破、产后心肺复苏、生后第1天机械通气能增加EOS发生风险，机械通气能增加LOS发生风险。 |
| 关键词: 极低出生体质量儿 超低出生体质量儿 败血症 病原菌 危险因素 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.02.005 |
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| 基金项目: |
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| Etiology and Risk Factors of Sepsis in Very Low/Extremely Low Birth Weight Infants in a Children’s Hospital from 2012 to 2017 |
| Qin Gaoyang, Yu Jialin |
| (Children’s Hospital of Chongqing Medical University, Chongqing 400014, China) |
| Abstract: |
| Objective: To analyze the pathogen distribution of early-onset sepsis (EOS) and late-onset sepsis (LOS) in very low/extremely low birth weight infants in our hospital, and explore its risk factors. Methods: The clinical data of very low/extremely low birth weight infants admitted to our hospital from 2012 to 2017 were collected, and all patients were divided into the EOS group, the LOS group and the control group (without sepsis). The incidence, pathogen spectrum and risk factors of sepsis were analyzed retrospectively. Results: A total of 777 very low/extremely low birth weight infants were included, including 106 cases (13.6%) in the EOS group and 245 cases (31.5%) in the LOS group. A total of 9 strains of EOS pathogenic bacteria were cultivated, of which Escherichia coli accounted for 44.4%; Klebsiella pneumoniae accounted for 39.2% of the 130 strains of LOS pathogenic bacteria. The rates of premature rupture of membranes, postpartum cardiopulmonary resuscitation and mechanical ventilation on the first day after birth in the EOS group were higher than those in the control group (P<0.05). The probability of mechanical ventilation in the LOS group was higher than that of the control group, and the probability of cesarean section was lower than that of the control group (P<0.05). Conclusion: Premature rupture of membranes, postpartum cardiopulmonary resuscitation and mechanical ventilation on the first day after birth can increase the risk of EOS, and mechanical ventilation can increase the risk of LOS. |
| Key words: very low birth weight extremely low birth weight sepsis pathogens risk factors |
