| 摘要: |
| [摘要]目的：系统评价益生菌预防儿童泌尿系感染的有效性。方法：检索有关数据库，纳入益生菌预防患儿泌尿系感染的相关随机对照试验（RCT），检索时间为建库至2019年3月。按纳入标准与排除标准筛选文献、提取资料并评价纳入研究的方法学质量后，采用RevMan 5.3软件进行Meta分析。结果：7项RCT纳入分析，包括1 879例患儿，治疗组938例，对照组941例。治疗组患者使用的药物包括乳酸杆菌、双歧杆菌、罗伊乳杆菌等，对照组患者使用的药物包括安慰剂和呋喃妥因等抗菌药物。Meta分析结果显示，治疗组与对照组预防儿童泌尿系感染的疗效上差异无统计学意义[OR=0.89, 95%CI：0.52~1.54, P=0.69]。结论：根据目前相关研究，益生菌对预防泌尿系感染无显著优势。 |
| 关键词: 益生菌 泌尿系感染 儿童 Meta分析 随机对照试验 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2020.05.005 |
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| 基金项目:国家卫生和计划生育委员会购买服务项目,药政[2016]61 号。 |
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| Systematic Review and Meta-Analysis on Efficacy of Probiotics in Prevention of Children with Urinary Tract Infection |
| Tian Chao, Shi Qiang, Wang Xiaoling |
| (National Center for Chidren’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China) |
| Abstract: |
| [Abstract] Objective: To systematically review the efficacy of probiotics in prevention of children with urinary tract infection. Methods: Databases were retrieved to collect randomized controlled trial (RCT) related to probiotics in prevention of children with urinary tract infection. The retrieval time was from the establishment of the database to Mar. 2019. After screening the literature according to the inclusion criteria and exclusion criteria, extracting the data and evaluating the methodological quality of the included literature, Meta-analysis was performed by using RevMan 5.3 software. Results: A total of seven RCT were collected, including 1,879 children, with 938 cases in the treatment group and 941 cases in the control group. The treatment group was given lactobacillus, bifidobacterium lactis and lactobacillus reuteri, while the control group received placebo and macrodantin. Meta-analysis results showed that there was no statistically significant difference between two groups in prevention of urinary tract infection [OR=0.89, 95%CI: from 0.52 to 1.54, P=0.69]. Conclusion: According to current relevant research, probiotics have no significant advantage in prevention of urinary tract infection. |
| Key words: probiotics urinary tract infection children Meta-analysis randomized controlled trial |
