| 摘要: |
| 目的：探讨临床药师在重症感染患儿抗感染治疗中的作用。方法：临床药师参与1例耐碳青霉烯类大肠埃希菌（CRE）并耐甲氧西林表皮葡萄球菌（MRSE）感染患儿的药学监护， 协助医师调整、制定药物治疗方案。结果：临床药师应用专业知识，结合患儿的生理病理情况，利用药物代谢动力学/药物效应动力学（PK/PD）参数优化抗感染治疗方案；患儿感染指标明显好转，病情稳定出院。结论：临床药师可以PK/PD角度作为切入点，将药学理论与临床实践相结合，协助医师制定有效的用药方案，成为治疗团队的重要组成部分。 |
| 关键词: 耐碳青霉烯类大肠埃希菌 耐甲氧西林表皮葡萄球菌 感染 药学监护 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2020.07.011 |
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| 基金项目:国家自然科学基金青年科学基金项目,编号21708005 |
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| Pharmaceutical Care for One Child Infected with Carbapene-Resistant Escherichia Coli and Meticillin Resistant Staphylococcus Aureus by Clinical Pharmacists |
| Fang Yuan1, Liu Xiumei1, Guo Qianqian1, Yuan Libo2 |
| (1.People’s Hospital of Zhengzhou, Henan Zhengzhou 450003, Chinia; 2. Henan University of Technology, Henan Zhengzhou 450001, Chinia) |
| Abstract: |
| Objective: To investigate the role of clinical pharmacists in anti-infection therapy for children with severe infection. Methods: The clinical pharmacists participated into the pharmaceutical care for one child infected with carbapene-resistant Escherichia coli (CRE) and meticillin resistant Staphylococcus aureus (MRSE), and assisted the clinicians to adjust and formulate medication regimens. Results: The clinical pharmacists applied professional knowledge, combined with the physiological and pathological conditions of children, and used pharmacokinetics/pharmacokinetics (PK/PD) parameters to optimize the anti-infection treatment regimens. The infection indexes of the child were significantly improved, and the child was discharged steadily. Conclusion: The clinical pharmacists can use the PK/PD parameters as an entry point to integrate pharmacy theory with clinical practice, assist the clinicians in developing the effective medication regimen, and become an important part of the therapeutic team. |
| Key words: carbapene-resistant Escherichia coli meticillin resistant Staphylococcus aureus infection pharmaceutical care |
