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| Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China |
| 20191498 |
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| (Qin Min, Wang Mo) |
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| 摘要: |
| 中央引导地方科技发展专项资金地方科技项目示范类项目;重庆市渝中区科技计划项目,编号2017045。 |
| 关键词: 盐酸普萘洛尔 口服混悬液 稳定性 儿童 |
| DOI：综述 |
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| 基金项目:Therapeutic Strategies for Refractory Nephrotic Syndrome Based on Pharmacogenomics |
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| 难治性肾病综合征基于药物基因组学的治疗策略 |
| 秦敏 综述，王墨 审校 |
| (重庆医科大学附属儿童医院，儿童发育疾病研究教育部重点实验室，国家儿童健康与疾病临床医学研究中心，儿童发育重大疾病国家国际科技合作基地，儿科学重庆市重点实验室，重庆 400014) |
| Abstract: |
| Objective: To prepare textemporaneously prepared oral suspension of propranolol hydrochloride in children that can be used in divided doses, and the preliminary stability test was conducted. Methods: The blank suspension was prepared by prescription screening and optimization, and the textemporaneously prepared oral suspension was prepared by adding finely-selled commercially available propranolol hydrochloride tablets. The content of propranolol hydrochloride in the suspension was determined by ultraviolet spectrophotometry at a wavelength of 289 nm. Preliminary stability investigation was carried out by centrifugation experiment and sample retention observation. Results: The prepared suspension was uniform, stable and dispersed, and all inspections complied with the relevant regulations. The average recoveries of the three experiments were 96.24%, 100.68%, and 95.10%, respectively (RSD were 4.04%, 0.82% and 0.86%, n=3). In the centrifuge experiment, the appearance of the sample was not stratified, and the finished product was observed to be stable for 10 d. Conclusion: The preparation process is simple and convenient, and the drug dispersion is simple and rapid. The method of content determination is accurate and reliable, with stable properties of finished products. |
| Key words: propranolol hydrochloride oral suspension stability children |
