| 摘要: |
| 目的：研究氯霉素泼尼松搽剂的抗炎、抗过敏和止痒作用，为临床应用提供参考。方法：利用二甲苯诱导小鼠耳朵肿胀观察其抗炎作用；利用2，4-二硝基氯苯（DNCB）诱导小鼠迟发性过敏反应观察其抗过敏作用；利用4-氨基吡啶(4-AP)诱导小鼠皮肤过敏性瘙痒观察其止痒作用。结果：与模型对照组比较，氯霉素泼尼松搽剂能显著减轻二甲苯所致小鼠耳朵肿胀程度，同时降低DNCB诱导的小鼠过敏反应，并能明显减少4-AP诱导小鼠瘙痒的舔体次数、延长瘙痒潜伏期、缩短瘙痒持续时间。结论：氯霉素泼尼松搽剂具有明显的抗炎、抗过敏和止痒作用。 |
| 关键词: 氯霉素泼尼松搽剂 抗炎 抗过敏 止痒 |
| DOI：doi:10.13407/j.cnki.jpp.1672.108X.2020.12.001 |
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| 基金项目:十堰市太和医院院级基金项目，编号2017JJXM056 |
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| Experimental Study on Anti-Inflammatory, Anti-Allergic and Anti-Pruritic Effects of Chloramphenicol Prednisone Liniment in Animals |
| Chen Shaoxiu, Du Xiao, Jing Haixia, Zhang Xia, Chang Mingquan |
| (（Shiyan Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Hubei Shiyan 442000, China）) |
| Abstract: |
| Objective: To study the anti-inflammatory, anti-allergic and anti-pruritic effects of chloramphenicol prednisone liniment in animals, so as to provide reference for clinical application. Methods: Anti-inflammatory effects of chloramphenicol prednisone liniment were observed in mice with xylene-induced ear swelling. Anti-allergic effects of chloramphenicol prednisone liniment were observed in mice with delayed-type hypersensitivity induced by 2, 4-dinitrochlorobenzene (DNCB). Anti-pruritus effects of chloramphenicol prednisone liniment were observed in mice with skin allergic itching induced by 4-aminopyridine (4-AP). Results: Compared with the model control group, chloramphenicol prednisone liniment could significantly alleviate xylene-induced ear swelling in mice and reduce DNCB-induced allergic reaction in mice. Chloramphenicol prednisone liniment could reduce the number of carcasses induced by 4-AP in mice, prolong pruritus latency and shorten the duration of pruritus. Conclusion: Chloramphenicol prednisone liniment has significant anti-inflammatory, anti-allergic and anti-pruritus effects. |
| Key words: chloramphenicol prednisone liniment anti-inflammatory anti-allergic anti-pruritus |
