| 摘要: |
| 目的：探讨外周血纤维蛋白降解产物（FDP）、单核细胞/淋巴细胞比值（MLR）、中性粒细胞/淋巴细胞比值（NLR）水平变化对重症肺炎患儿生存预后的影响。方法：选取2015年1月至2018年1月重庆市大足区人民医院收治的肺炎患儿310例，根据患儿病情的严重程度分为重症肺炎患儿162例（重症肺炎组）、普通肺炎患儿148例（普通肺炎组），另选取健康体检儿童58例（对照组），检测并比较各组外周血FDP水平、NLR、MLR，分析外周血FDP水平、MLR、NLR变化对重症肺炎患儿生存预后的预测价值。结果：重症肺炎组患儿外周血FDP水平、NLR、MLR分别高于普通肺炎组、对照组，普通肺炎组外周血FDP水平、NLR、MLR高于对照组（P<0.05）。重症肺炎死亡组患儿外周血FDP水平、MLR、NLR高于存活组患儿，差异有统计学意义（P<0.05）。多因素Logistic分析显示，外周血FDP水平、MLR、NLR升高是影响重症肺炎患儿生存预后的独立危险因素。ROC曲线结果显示，外周血FDP、MLR、NLR联合检测预测重症肺炎患儿生存预后的曲线下面积为0.891，敏感度和特异度分别为0.914和0.813。结论：外周血FDP水平、MLR、NLR变化是影响重症肺炎患儿预后的独立危险因素，FDP、MLR、NLR升高对重症肺炎患儿生存预后具有良好预测评估价值。 |
| 关键词: 纤维蛋白降解产物 单核细胞/淋巴细胞值 中性粒细胞/淋巴细胞值 重症肺炎 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.02.002 |
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| 基金项目:重庆市卫生和计划生育委员会医学科研计划项目,编号2017ACC1029 |
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| Evaluation Value of Fibrin Degradation Products, Monocyte/Lymphocyte Ratio and Neutrophils/Lymphocyte Ratio in Peripheral Blood for Prognosis of Children with Severe Pneumonia |
| Li Xiaomei, Xia Hong, Zheng Yinglian, Mao Guoqi |
| (Dazu Hospital, The First Affiliated Hospital of Chongqing Medical University, The People’s Hospital of Dazu, Chongqing 402360, China) |
| Abstract: |
| Objective: To investigate the effects of fibrin degradation products (FDP), monocyte/lymphocyte ratio (MLR) and neutrophil/lymphocyte ratio (NLR) in peripheral blood on survival and prognosis in children with severe pneumonia. Methods: A total of 310 children with pneumonia admitted into The People’s Hospital of Dazu from Jan. 2015 to Jan. 2018 were extracted to be divided into 162 children with severe pneumonia (severe pneumonia group) and 148 children with common pneumonia (common pneumonia group) according to the severity of the disease. And 58 healthy children were extracted as the control group. Levels of FDP, NLR and MLR in peripheral blood were detected and compared, and the predictive value of FDP, MLR and NLR in peripheral blood on the survival prognosis of children with severe pneumonia was analyzed. Results: The levels of FDP, NLR and MLR in severe pneumonia group were respectively higher than those in the common pneumonia group and the control group, and the levels of FDP, NLR and MLR in the common pneumonia group were higher than those in the control group (P<0.05). The levels of FDP, MLR and NLR in peripheral blood in the severe pneumonia death group were higher than those in the survival group, with statistically significant difference (P<0.05). Multivariate Logistic analysis showed that elevated levels of FDP, MLR, and NLR in peripheral blood were independent risk factors affecting the survival and prognosis of children with severe pneumonia. The results of ROC curve showed that the area under the curve for predicting the survival and prognosis of children with severe pneumonia by combined detection of FDP, MLR, and NLR in peripheral blood was 0.891, and the sensitivity and specificity were 0.914 and 0.813, respectively. Conclusion: Changes of FDP, MLR, and NLR in peripheral blood are independent risk factors that affect the prognosis of children with severe pneumonia. Elevated FDP, MLR and NLR have significant predictive value for the survival and prognosis of children with severe pneumonia. |
| Key words: fibrin degradation products monocyte/lymphocyte ratio neutrophil/lymphocyte ratio severe pneumonia |
