| 摘要: |
| 目的：探讨口服缬更昔洛韦治疗先天性巨细胞病毒感染新生儿的疗效。方法：口服缬更昔洛韦16 mg/kg，每日2次，治疗1例先天性巨细胞病毒感染新生儿6周，监测体质量、头围、中性粒细胞、血小板、直接胆红素、丙氨酸氨基转移酶及病毒载量，随访头颅超声、脑干听性诱发电位和头颅MRI。结果：缬更昔洛韦治疗后尿液中和血液中病毒载量转阴，听力和发育结果有改善，治疗期间出现粒细胞减少症，治疗结束后好转。结论：口服缬更昔洛韦治疗先天性巨细胞病毒感染有疗效，需进一步研究确定最佳剂量、疗程以达到最好的疗效和安全性 |
| 关键词: 先天性 巨细胞病毒感 缬更昔洛韦 新生儿 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2021.02.004 |
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| 基金项目:江苏省妇幼健康科研项目,编号F201609 |
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| Oral Valganciclovir in the Treatment of Neonatal Congenital Cytomegalovirus Infection: a Case Report |
| Yang Lili, Pan Zhaojun, Wang Jing, Lu Xiuli |
| (Huai’an Maternity and Child Healthcare Hospital, Jiangsu Huaian 223002, China) |
| Abstract: |
| Objective: To probe into the efficacy of oral valganciclovir in the treatment of a case of neonatal congenital cytomegalovirus infection. Methods: A newborn with congenital cytomegalovirus infection was treated with oral administration of 16 mg/kg bid valganciclovir for 6 weeks. Body weight, head circumference, neutrophils, platelets, direct bilirubin, alanine aminotransferase and viral load were monitored; and follow-up was performed on cranial ultrasound, brainstem auditory evoked potential and head magnetic resonance imaging (MRI). Results: At the end of therapy, the newborn was negative for cytomegalovirus in urine and plasma, the hearing and developmental results were improved. Granulocytopenia that occurred during treatment were improved after treatment. Conclusions: Oral valganciclovir is effective in the treatment of congenital cytomegalovirus infection, and further research is needed to determine the optimal dose and course of treatment to achieve better efficacy and safety. |
| Key words: congenital cytomegalovirus valganciclovir newborn |
