| 摘要: |
| 目的:探讨儿童激素性股骨头坏死的高危因素及预防儿童激素性股骨头坏死的药学干预措施。方法:回顾分析1 例长
期大剂量使用糖皮质激素(GC)引发股骨头坏死的病例,通过查阅文献对患者的年龄、性别、激素使用剂量、基因多态性等因素
进行分析,探讨患儿发生激素性股骨头坏死的高危因素以及预防儿童激素性股骨头坏死的药学干预措施。结果:年龄>10 岁、
每日使用大剂量激素治疗、接受激素冲击治疗是发生激素性股骨头坏死的高危因素。基因多态性与激素性股骨头坏死的相关
性研究仍缺乏定论。为减少激素性股骨头坏死的发生,对于存在高危因素的患者应注意进行钙剂和维生素D 的补充,必要时
可考虑联用双磷酸盐预防治疗,但应注意进行相关的评估和用药监测。结论:年龄和糖皮质激素使用剂量是儿童激素性股骨头
坏死的高危因素,对于存在高危因素的患者,应注意钙剂、维生素D 以及双磷酸盐的补充。 |
| 关键词: 糖皮质激素 股骨头坏死 高危因素 儿童 |
| DOI：doi:10.13407/ j.cnki.jpp.1672.108X.2022.04.005 |
|
| 基金项目: |
|
| Glucocorticoid-Induced Avascular Necrosis of Femoral Head in Children: a Case Report and Analysis of High Risk Factors |
| Li Beibei1,2 , Jiang Zhihu1 , Sun Huajun1 , Li Zhiling1 , Liu Hongxia1 |
| (1. Shanghai Children's Hospital, Children's Hospital
of Shanghai Jiao Tong University, Shanghai 200062, China; 2. Xiangyang No. 1 People,s Hospital, Hubei University of Medicine,
Hubei Xiangyang 441000, China)) |
| Abstract: |
| Objective: To probe into the high risk factors for steroid-induced avascular necrosis of femoral head in children and order to reduce the incidence of steroid-induced avascular necrosis of femoral head, patients with high risk factors should be
supplemented with calcium and vitamin D, if necessary, bisphosphonate prophylaxis were supposed to be considered. However, attention
should be paid to relevant assessment and medication monitoring. Conclusion: Age and daily dose of glucocorticoid are high risk factors
for steroid鄄induced avascular necrosis of femoral head in children. For patients with high risk factors, calcium, vitamin D and
bisphosphonate supplementation are necessary.
[Keywords]glucocorticoid; avascular necrosis of
pharmaceutical intervention measures for prevention of steroid鄄induced avascular necrosis of femoral head in children. Methods: A case
of long鄄term high鄄dose glucocorticoid (GC)鄄induced avascular necrosis of femoral head was retrospectively analyzed. The age, gender,
daily dose of glucocorticoid, genetic polymorphism were analyzed by retrieving the literature to explore the high risk factors for steroid-
induced avascular necrosis of femoral head in children and pharmaceutical intervention measures for prevention. Results: Age >10
years, high daily dose of glucocorticoid, and glucocorticoid pulse therapy were high risk factors for steroid鄄induced avascular necrosis of
femoral head. Correlation between gene polymorphism and steroid-induced avascular necrosis of femoral head was still inconclusive. In
pharmaceutical intervention measures for prevention of steroid鄄induced avascular necrosis of femoral head in children. Methods: A case
of long-term high-dose glucocorticoid (GC)-induced avascular necrosis of femoral head was retrospectively analyzed. The age, gender,
daily dose of glucocorticoid, genetic polymorphism were analyzed by retrieving the literature to explore the high risk factors for steroid-
induced avascular necrosis of femoral head in children and pharmaceutical intervention measures for prevention. Results: Age >10
years, high daily dose of glucocorticoid, and glucocorticoid pulse therapy were high risk factors for steroid-induced avascular necrosis of
femoral head. Correlation between gene polymorphism and steroid-induced avascular necrosis of femoral head was still inconclusive. In |
| Key words: glucocorticoid avascular necrosis of femoral head high risk factors children |
